NIH GUIDE, Volume 22, Number 7, February 19, 1993


P.T. 34


  Tissue Culture 

  Biology, Cellular 

National Cancer Institute

The National Cancer Institute (NCI), Division of Cancer Prevention

and Control, in its annual requirement to seek new sources, is

soliciting proposals for the Early Detection Research Network (EDRN)

to increase the number of Master Agreement (MA) holders originally

awarded under MAA No. NCI-CN-15340-04.  Current MA holders for this

program are not required to submit a proposal.  The required service

will be defined by Master Agreement Orders issued during the period

of performance.

The scope of the Master Agreement includes:  (1) establishment of a

tissue bank of normal, premalignant, and malignant tissues by the

collection and storage of tissues and associated fluids in order to

identify potential cellular and molecular markers for early

detection. Initially, the project will focus on tissues of the colon

and rectum, lung, prostate, and urinary bladder.  In addition, there

will be an associated database with demographic information, exposure

to potential carcinogens and risk factors on the subjects from whom

specimens have been obtained; and (2) coordinate cellular and

molecular studies on these tissues with the goal of developing new

procedures assessing the sequence of genetic alterations in

protooncogenes, analyzing allelic deletions of suppressor genes,

identifying activated oncogenes, identifying oncogene products

suitable for evaluating neoplastic progression, and developing

cellular and molecular markers that will identify individuals who are

at high risk of cancer.


Requests for this solicitation must be in writing and reference MAA

No. NCI-CN-35537-50.  The Master Agreement Announcement (MAA) will be

available approximately February 25, 1993, and responses will be due

by COB April 8, 1993.  Requests are to be addressed to:

Ms. Karen L. McFarlane, Contract Specialist

Research Contracts Branch, PCCS

National Cancer Institute

Executive Plaza South, Room 635

Bethesda, MD  20892

Telephone:  (301) 496-8603


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