PROSTAGLANDINS EXCRETION IN PREECLAMPSIA

NIH GUIDE, Volume 22, Number 5, February 5, 1993



RFP AVAILABLE:  NICHD-DESPR-93-02



P.T. 34



Keywords:

  Prostaglandins 

  Pregnancy 



National Institute of Child Health and Human Development



The National Institute of Child Health and Human Development (NICHD)

is planning a study to determine whether or not urinary excretion of

prostaglandin metabolites is altered in preeclamptic patients before

the clinical onset of disease, and to determine the effect of oral

calcium supplementation during pregnancy on the excretion of these

metabolites.  This will be a nested case control study using stored

urine specimens collected at specified times during pregnancy from

pregnant women participating in the NICHD Trial of Calcium for

Preeclampsia Prevention (CPEP).  This trial, which recently has been

initiated by the NICHD at five universities across the country, is a

randomized clinical trial designed to determine whether or not oral

calcium supplementation will prevent preeclampsia.  The contractor

will be expected to measure metabolites of prostacyclin and

thromboxane in approximately 700 urine specimens selected by the

Project Officer over the course of two years.  The NICHD expects to

make one award from this solicitation.



This announcement is a new solicitation.  The issuance of this

Request for Proposals (RFP) will be on or about February 19, 1993,

and proposals are due by 4:00 p.m. (local time), April 16, 1993.  A

short-form version of the RFP will be provided first.  This includes

the Statement of Work, Technical Reporting Requirements, Background

Information, and the Evaluation Criteria to be used for selection of

the awardee.  After examining this, a full-text version of the RFP

must be requested, in writing, for those organizations interested in

responding.



INQUIRIES



Organizations desiring a copy of the short-form RFP may send their

written request to:



Mrs. Lynn Salo

Office of Grants and Contracts

National Institute of Child Health and Human Development

6100 Building, Room 7A07

Bethesda, MD  20892

FAX:  (301) 402-3676



FAX requests are acceptable.  All requests must cite the RFP number

NICHD-DESPR-93-02 and include two self-addressed mailing labels.  All

sources that consider themselves qualified are encouraged to submit a

proposal.  This advertisement does not commit the government to make

an award.



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