NIH GUIDE, Volume 22, Number 1, January 8, 1993


P.T. 34


  Viral Studies (Virology) 

  Screening of Drugs/Agents 



National Institute of Allergy and Infectious Diseases

The Antiviral Research Branch of the Division of Microbiology and

Infectious Diseases, National Institute of Allergy and Infectious

Diseases (NIAID), has a requirement for investigators to perform in

vitro screening of compounds for their ability to inhibit the growth

and/or replication of herpes viruses (HSV, CMV, VZV, EBV) and

respiratory viruses (influenza, parainfluenza, respiratory syncytial

virus, measles).  The contractor(s) will provide the necessary

equipment, personnel, facilities, and materials to screen 200

compounds annually.  The contractor(s) will be responsible for

determining a compound's antiviral activity, cytotoxicity, and

selective index.  Research on the development of improved screening

methodology, studies on mechanism of action, and studies of efficacy

of drug combinations will be encouraged as an adjunct to the primary

antiviral evaluation.

It is anticipated that either one cost-reimbursement, completion,

contract covering all virus classes or two cost-reimbursement,

completion, contracts covering the virus classes individually will be

awarded for a period of five years.  This is an announcement for an

anticipated Request for Proposals (RFP).  RFP NIH-NIAID-DMID-93-07

will be issued on or about December 28, 1992, with a closing date

tentatively set for March 5, 1993.


Requests for the RFP are to be directed in writing to:

Sara Southard, Contract Specialist,

Contract Management Branch

National Institute of Allergy and Infectious Diseases

Solar Building, Room 3C07

6003 Executive Boulevard

Bethesda, MD  20892

To receive a copy of the RFP, supply this office with two

self-addressed mailing labels.  All responsible sources may submit a

proposal that will be considered by the government.  This

advertisement does not commit the government to award a contract.


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