NIH GUIDE, Volume 21, Number 45, December 18, 1992


P.T. 34



  Infectious Diseases/Agents 

  Screening of Drugs/Agents 

National Institute of Allergy and Infectious Diseases

The Development Therapeutics Branch, Basic Research and Development

Program, Division of AIDS of the National Institute of Allergy and

Infectious Diseases (NIAID), is soliciting proposals from offerors

with the capability to evaluate therapeutic agents for efficacy

against Toxoplasma gondii encephalitis and latent toxoplasma

infection in a rodent model.  The contractor will evaluate

therapeutic agents supplied or approved by the Project Officer for

efficacy against Toxoplasma gondii in both rodent and in vitro

models.  During evaluations, the contractor may need to modify,

improve or otherwise further characterize the rodent model and or in

vitro model or develop other models to improve model utility in the

evaluation of therapies.  The Contractor may also be required to

design alternative protocols and to conduct additional studies for

detailed evaluation of promising therapeutic regimens.

Offerors must have in vivo and in vitro models available at the time

of proposal.  Past experience with animal models for Toxoplasmosis,

the availability of the animals and strains of Toxoplasma gondii, and

drug testing capability must be documented.  This contract will be

used to assist in the development of anti-infective therapies, to

better understand the potential adverse health effects of such

clinical trials.

This is an announcement for an anticipated Request for Proposal

(RFP).  The issuance of the RFP NIH-NIAID-DAIDS-93-25 will be on or

about December 28, 1992, and proposals will be due by COB on or about

March 24, 1993.  It is anticipated that one cost-reimbursement

contract will be awarded as a result of this solicitation and that

the contract will have a five year period of performance.


To receive a copy of the RFP, provide this office with three

self-addressed mailing labels.  Telephone inquiries will not be

honored and all inquiries must be in writing.  Requests for the RFP

are to be directed to:

Mr. Ross Kelley

Contract Management Branch

National Institute of Allergy and Infectious Diseases

Solar Building, Room 3C-07

6003 Executive Boulevard

Bethesda, MD  20892

Telephone:  (301) 496-2509

FAX:  (301) 402-0972

A short-form version of the RFP will be provided first, which

includes the Statement of Work, Reporting Requirements, and the

Evaluation Criteria to be used for selection of the awardee.  After

examining this, a full-text version of the RFP must be requested, in

writing, for those offerors interested in responding.  FAX requests

are acceptable for the full text version only.  All proposals from

responsible sources will be considered by the NIAID.  This

advertisement does not commit the Government to award a contract.


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