NIH GUIDE, Volume 21, Number 43, November 27, 1992


P.T. 34




  Recombinant DNA 


National Institute of Allergy and Infectious Diseases

The National Institute of Allergy and Infectious Diseases (NIAID) has

a requirement for a malaria vaccine design.  This requirement is for

a facility and team of scientists to synthesize, using recombinant

DNA technology, and to express biological constructs encoding

polypeptide products based on malaria antigens.  This requirement is

part of a cooperative initiative with the Agency for International

Development.  Respondents must have facilities and equipment to allow

the construction of recombinant antigen genes from know sequences and

cloned DNA specimens, the efficient expression of polypeptide

products of such recombinant gene constructs, and protein

purification.  Quality control, including assessment of protein

purity and immunologic evaluation of synthesized polypeptide products

in animal models, must also be a part of the capability.  The

government will work closely with the contractor in the selection and

design of the candidate genes and expression systems.  The contractor

will also participate and assist in development of Investigational

New Drugs (IND) applications.  Scaled-up production according to

current Good Manufacturing Practices, clinical trials, and aspects of

the preclinical evaluation of the polypeptide products of the

recombinant genetic constructs, will be conducted at other


Any contract awarded will be subject to DHHS regulations regarding

the animal subjects in research.  One contract may be awarded as a

result of this solicitation.  It is expected that the contract will

have a three-year period of performance.  The issuance of the

Requests for Proposals (RFP) will be on or about November 23, 1992

and proposals will be due by the close of business on January 15,

1993. Any responsible offeror may submit a proposal that will be

considered by the Government.


To receive a copy of the RFP, provide this office with two

self-addressed mailing labels.  Requests for the RFP may be directed


Merilee Rahe-Stoline

Contract Specialist, Contract Management Branch

National Institute of Allergy and Infectious Diseases

6003 Executive Boulevard, Room 3C07

Bethesda, MD  20892

This advertisement does not commit the Government to award a



Return to 1992 Index

Return to NIH Guide Main Index

Office of Extramural Research (OER) - Home Page Office of Extramural
Research (OER)
  National Institutes of Health (NIH) - Home Page National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, Maryland 20892
  Department of Health and Human Services (HHS) - Home Page Department of Health
and Human Services (HHS) - Government Made Easy

Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.