LABORATORY FOR ASSESSMENT OF MUCOSAL IMMUNE RESPONSES INDUCED BY AIDSVACCINES IN CLINICAL TRIAL VOLUNTEERS NIH GUIDE, Volume 21, Number 41, November 13, 1992 RFP AVAILABLE: NIAID-DAIDS-93-18 P.T. 34 Keywords: AIDS Vaccine Bioassay Immunology National Institute of Allergy and Infectious Diseases The National Institute of Allergy and Infectious Diseases (NIAID), NIH, has a requirement to provide for the centralized performance of immunological assays to evaluate HIV-specific humoral and cellular mucosal immune responses in support of clinical trials of prototype AIDS vaccines. The purpose of this contract is to support the NIAID in its mission to stimulate research towards discovery and testing of prototype vaccines for the acquired immunodeficiency syndrome (AIDS). The NIAID requires a Mucosal Immunology Laboratory to evaluate reproductive tract, gut, blood, and other mucosal specimens from vaccine clinical trial volunteers for humoral and cellular mucosal immune responses induced by immunization with prototype AIDS vaccines. This effort will support the research of AIDS investigators, including the AIDS Vaccine Evaluation Group (AVEG), the National Cooperative Vaccine Evaluation Groups (NCVDG), and other programs initiated by NIAID. Specifically, the selected Contractor shall be responsible for: (1) performing specific immunological assays for detection of HIV-specific antibody and cellular responses in mucosal site and blood specimens from AIDS vaccine recipients; (2) developing standard protocols for the collection, processing, and storage of mucosal specimens at the vaccine trial sites; (3) receiving, cataloging, tracking, coding, storing, and maintaining an inventory of vaccinee specimens arriving for evaluation; and (4) maintaining a test result database and transferring data electronically to the AIDS Vaccine Clinical Trials Network (AVCTN) Data Coordinating and Analysis Center (DCAC). This is an announcement for an anticipated Request for Proposals (RFP). RFP: NIH-NIAID-DAIDS-93-18 will be issued on or about November 13, 1992 with a closing date tentatively set for January 5, 1993. It is expected that one (1) contract will be awarded as a result of this solicitation. It is expected that the contract will have a five-year period of performance, and a completion type cost-reimbursement contract is anticipated. INQUIRIES Requests for the RFP may be directed in writing to: Lawrence Butler, Contracting Officer Contract Management Branch National Institute of Allergy and Infectious Diseases Solar Building, Room 3C-07 6003 Executive Boulevard Bethesda, MD 20892 Please provide this office with three self-addressed mailing labels. Telephone inquiries will not be honored and all inquiries must be in writing. A short-form version of the RFP will be provided first, which includes only the statement of work and the Evaluation Criteria to be used for selection of the awardee. After examining this, a full-text version of the RFP must be requested in writing by those offerors interested in responding. FAX requests are acceptable for the full-text version of the RFP only (FAX: 301-402-0972). All proposals from responsible sources will be considered by the NIAID. This advertisement does not commit the Government to award a contract. .
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