SYNTHESIS OF CHEMICAL MODIFIERS OF RADIATION RESPONSE

NIH GUIDE, Volume 21, Number 33, September 11, 1992



RFP AVAILABLE: NCI-CM-37828-75



P.T. 34



Keywords:

  Radiotherapy 

  Chemical Synthesis 

  Drug Design 



National Cancer Institute



The Radiotherapy Development Branch, Radiation Research Program,

Division of Cancer Treatment , National Cancer Institute is seeking

organizations with the capability to design, synthesize, and

characterize new and novel chemical modifiers of radiation response.

Classes of interest are:  bioreductive agents, agents that exploit

tumor pathophysiology, inhibitors of repair of radiation damage, and

free radical base agents.  The project requires designated data

obtained from in vitro testing of synthesized compounds and data

regarding the efficacy in vivo of designated compounds with significant

activity in vitro.



The offeror should include an experienced radiobiologist and an

experienced synthetic organic chemist on the project team, and the

Principal Investigator should possess a doctorate in a relevant

science.  In addition, the offeror must be AAALAC accredited or

equivalent and be capable of maintaining a conventional rodent colony

of at least 400 mice.  The offeror must also have radiation capability

suitable for irradiating mice and cell cultures.  Equipment for

physicochemical and pharmacological analysis (e.g., UV, IR, NMR, HPLC,

and polargraphic or pulse radiolysis for measuring electron affinity,

when appropriate) of compounds to be synthesized is also required.



RFP No. NCI-CM-37828-75 will be issued, upon written request to Bernice

Evans, Contract Specialist, on or about August 10, 1992, with a due

date for receipt of proposals on December 15, 1992.  It is anticipated

that an incrementally funded contract will be awarded for a period of

four years beginning on or about June 30, 1993.  This project is a

recompetition of the work being done under Contract No. NO1-CM-07321 by

Auckland UniService, Ltd., Auckland, New Zealand. (249)  No collect

calls will be accepted.



Copies of the RFP may be obtained by sending a written request to:



Ms. Bernice Evans

National Cancer Institute

Research Contracts Branch, TCS

Executive Plaza South, Room 603

Bethesda, MD  20892

Telephone:  (301) 496-8620



.

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