NIH GUIDE, Volume 21, Number 20, May 29, 1992




P.T. 34



  Tissue Culture 


  Mental Retardation 

  Learning Disorders+ 

  Sudden Infant Death Syndrome 


National Institute of Child Health and Human Development


The National Institute of Child Health and Human Development (NICHD) is

planning to establish an additional repository to collect, store, and

distribute specimens from infants and children with neurodevelopmental

disorders both from "unaffected" (control) individuals and from

individuals with developmental disorders.  The biopsy and/or autopsied

tissues to be included in the brain and tissue bank would encompass the

following disorders:  diagnosed Down's syndrome, other chromosome

defects, mitochondrial encephalopathies, phenylketonuria and other

aminoacidopathies, maternal phenylketonuria, Rett syndrome,

leukodystrophies, lysosomal disorders, unexplained forms of mental

retardation, sudden infant death syndrome (SIDS), dyslexia, autism, and

other neurodevelopmental disorders.  Specific tissues to be collected

will include the following:  brain, spinal cord, cerebrospinal fluid,

blood and serum, peripheral nerves, liver, kidney, pancreas, lungs,

spleen, adrenal, skeletal muscles, heart, skin, thyroid, lymph nodes,

and gonads.  Tissues would be obtained premortem, postmortem, and from

abortions.  These tissues will be made available to qualified

investigators to support and facilitate research that will lead to an

improved understanding of the etiology, pathology, pathogenesis, and

clinical-pathological correlation of conditions that are associated

with mental retardation, learning and behavioral deficits, and SIDS.


This announcement for a brain and tissue bank is a new solicitation

that will be performed in collaboration with an existing procurement

(N01-HD-1-3138--University of Maryland, Baltimore).  The Project

Officers will create a steering committee to foster this collaboration.

The offeror shall not arrange the joint endeavor.


The issuance of this Request for Proposals (RFP) will be on or about

June 1, 1992 and proposals are due by 4:00 p.m. (Local Time), August 3,

1992.  Those organizations desiring a copy of the above RFP may send a

written request to Mrs. Lynn Salo at the address listed below.  All

requests must cite the RFP number above and include two self-addressed

mailing labels.  All sources who consider themselves qualified are

encouraged to submit a proposal.  This advertisement does not commit

the Government to award a contract.


Mrs. Lynn Salo

Contract Specialist

National Institute of Child Health and Human Development

Office of Grant and Contracts

Contract Management Branch

6100 Executive Boulevard, Room 7A07R

Rockville, MD  20852

Telephone:  (301) 496-4611



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