NIH GUIDE, Volume 21, Number 14, April 10, 1992




P.T. 34






National Cancer Institute


The National Cancer Institute (NCI) is seeking investigators in a

collaborative effort to continue follow-up of surviving members of a

cohort exposed to DES given in pregnancy and designated unexposed

comparison subjects.  Each cohort shall consist of at least 300

people (mothers, daughters, and sons).  The combined cohort

(inclusive of all collaborative investigators) shall include at least

3,500 people exposed in utero (daughters and sons) and at least 2,600

women exposed during pregnancy (mothers).  Unexposed subjects that

can be compared to daughters or sons shall be included, but unexposed

subjects comparable to mothers shall not.  It is anticipated that

outcomes shall be ascertained by questionnaire and record review, not

by clinical examination. Clinical examinations shall be conducted

only for cohort members who have not been examined before, for

example, new entrants.  It should be noted that an offeror may

propose to provide the names, addresses, and other locating data to

NCI and not conduct follow-up of the cohort.  The contractor will

participate in all other contract activities, but the NCI will

provide for the follow-up of cohort members.  In addition, an offeror

may propose to participate in all other cohort activities but not to

conduct tracing of the cohort.  The NCI will trace the lost cohort

members.  These variations must be clearly noted in the proposals and

the subsequent budgets must be adjusted accordingly.  This project is

a research effort.  The NCI expects to make one cost-reimbursement,

completion type contract.  All responsible sources meeting the

criteria are encouraged to submit an offer that will be considered by

the NCI.  The Request for Proposals (RFP) was available on March 30,

1992.  The proposals are due by COB May 14, 1992 with the award

anticipated by September 30, 1992.  No collect calls will be

accepted.  Copies of the RFP may be obtained by submitting a written

request to:


Barbara A. Shadrick, Contract Specialist

Research Contracts Branch, OD

Cancer Etiology Contracts Section

National Cancer Institute

Executive Plaza South, Suite 620

Bethesda, MD  20892

Telephone:  (301) 496-8611



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