CONTINUATION OF FOLLOW-UP OF DES-EXPOSED COHORTS NIH GUIDE, Volume 21, Number 14, April 10, 1992 RFP AVAILABLE: NCI-CP-33011-21 P.T. 34 Keywords: Cancer/Carcinogenesis Epidemiology Pregnancy National Cancer Institute The National Cancer Institute (NCI) is seeking investigators in a collaborative effort to continue follow-up of surviving members of a cohort exposed to DES given in pregnancy and designated unexposed comparison subjects. Each cohort shall consist of at least 300 people (mothers, daughters, and sons). The combined cohort (inclusive of all collaborative investigators) shall include at least 3,500 people exposed in utero (daughters and sons) and at least 2,600 women exposed during pregnancy (mothers). Unexposed subjects that can be compared to daughters or sons shall be included, but unexposed subjects comparable to mothers shall not. It is anticipated that outcomes shall be ascertained by questionnaire and record review, not by clinical examination. Clinical examinations shall be conducted only for cohort members who have not been examined before, for example, new entrants. It should be noted that an offeror may propose to provide the names, addresses, and other locating data to NCI and not conduct follow-up of the cohort. The contractor will participate in all other contract activities, but the NCI will provide for the follow-up of cohort members. In addition, an offeror may propose to participate in all other cohort activities but not to conduct tracing of the cohort. The NCI will trace the lost cohort members. These variations must be clearly noted in the proposals and the subsequent budgets must be adjusted accordingly. This project is a research effort. The NCI expects to make one cost-reimbursement, completion type contract. All responsible sources meeting the criteria are encouraged to submit an offer that will be considered by the NCI. The Request for Proposals (RFP) was available on March 30, 1992. The proposals are due by COB May 14, 1992 with the award anticipated by September 30, 1992. No collect calls will be accepted. Copies of the RFP may be obtained by submitting a written request to: Barbara A. Shadrick, Contract Specialist Research Contracts Branch, OD Cancer Etiology Contracts Section National Cancer Institute Executive Plaza South, Suite 620 Bethesda, MD 20892 Telephone: (301) 496-8611 .
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