PERIPHERAL ARTERIAL DISEASE:  A PILOT STUDY TO EVALUATE TREATMENT AND PREVENTION
STRATEGIES FOR ATHEROSCLEROTIC CARDIOVASCULAR DISEASE--CLINICAL CENTERS

NIH GUIDE, Volume 21, Number 6, February 14, 1992

RFP AVAILABLE:  NHLBI-HC-92-11

P.T. 34

Keywords:
  Cardiovascular Diseases 
  Biochemical Markers 

National Heart, Lung, and Blood Institute

The National Heart, Lung, and Blood Institute (NHLBI) requires six
clinical centers to participate in a pilot study to evaluate the exact
dosage of various drugs and drug combinations, drug interactions, and
adverse effects by monitoring a variety of biochemical markers of
atherosclerotic cardiovascular disease.  This pilot study will also
assess the feasibility of conducting a full-scale trial among patients
with peripheral arterial disease (PAD).  The pilot study will employ a
factorial design in 600 participants with documented PAD (symptomatic
and asymptomatic).  The three interventions will consist of:  (1)
isolated increase in plasma HDL-C levels, (2) antithrombotic therapies
of warfarin and aspirin, and (3) antioxidant therapy.  The period of
performance is anticipated for three years beginning in September 1992.

This is an announcement of the availability of a Request for Proposals
(RFP).  RFP NHLBI-HC-92-11 will be available on or about February 11,
1992, with proposals due on April 24, 1992.  Six awards are anticipated
by the Government.  Offerors other than those in the North American
continent will not be considered.  Written requests for this RFP must
include three, self-addressed mailing labels and must cite RFP
NHLBI-HC-92-11.

Requests for copies of the RFP must be sent to:

Linda Y. Gardner
Contract Specialist
ECA Contracts Section
National Heart, Lung, and Blood Institute
Federal Building, Room 200
7550 Wisconsin Avenue
Bethesda, MD  20892


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