PERIPHERAL ARTERIAL DISEASE: A PILOT STUDY TO EVALUATE TREATMENT AND PREVENTION STRATEGIES FOR ATHEROSCLEROTIC CARDIOVASCULAR DISEASE--CLINICAL CENTERS NIH GUIDE, Volume 21, Number 6, February 14, 1992 RFP AVAILABLE: NHLBI-HC-92-11 P.T. 34 Keywords: Cardiovascular Diseases Biochemical Markers National Heart, Lung, and Blood Institute The National Heart, Lung, and Blood Institute (NHLBI) requires six clinical centers to participate in a pilot study to evaluate the exact dosage of various drugs and drug combinations, drug interactions, and adverse effects by monitoring a variety of biochemical markers of atherosclerotic cardiovascular disease. This pilot study will also assess the feasibility of conducting a full-scale trial among patients with peripheral arterial disease (PAD). The pilot study will employ a factorial design in 600 participants with documented PAD (symptomatic and asymptomatic). The three interventions will consist of: (1) isolated increase in plasma HDL-C levels, (2) antithrombotic therapies of warfarin and aspirin, and (3) antioxidant therapy. The period of performance is anticipated for three years beginning in September 1992. This is an announcement of the availability of a Request for Proposals (RFP). RFP NHLBI-HC-92-11 will be available on or about February 11, 1992, with proposals due on April 24, 1992. Six awards are anticipated by the Government. Offerors other than those in the North American continent will not be considered. Written requests for this RFP must include three, self-addressed mailing labels and must cite RFP NHLBI-HC-92-11. Requests for copies of the RFP must be sent to: Linda Y. Gardner Contract Specialist ECA Contracts Section National Heart, Lung, and Blood Institute Federal Building, Room 200 7550 Wisconsin Avenue Bethesda, MD 20892
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