SYNTHESIS AND TESTING OF MALE CONTRACEPTIVE AGENTS 

NIH GUIDE, Volume 21, Number 4, January 31, 1992

 

RFP AVAILABLE:  NICHD-CD-92-09

 

P.T. 34



Keywords:

  Chemical Synthesis 

  Biometry 

  Contraceptives 

 

National Institute of Child Health and Human Development

 

The Contraceptive Development Branch of the Center for Population

Research, National Institute of Child Health and Human Development, has

a requirement for the synthesis and testing of male contraceptive

agents.  The specific objectives of the project are the design,

synthesis, and testing of male contraceptive agents that inhibit

testicular sperm development, post-testicular sperm maturation, and

epididymal function.

 

Organizations must have adequate facilities and capabilities to carry

out the proposed synthetic chemical capabilities to carry out the

proposed synthetic chemical program.  Specifically excluded from this

project are LHRH analogs, gossypol derivatives, sex steroids, cytotoxic

agents, and all alkylating agents including chlorohydrin,

deoxyhalosugars, nitrogen mustards, ethyleneimines, and

sulfonoxyalkanes.  Non-specific antimetabolites, antimitotic agents, N-

Substituted diamines (such as WIN. 13,099), most major classes of

antibiotics, including the macrolides, aminoglycosides, penicillins,

tetracyclines, sulfasalazine, and co-trimoxazole, and nitroheterocyclic

compounds are also excluded.  Proposals to merely collect compounds

from various sources and/or only perform biological assays will not be

considered.

 

It is anticipated that four contract awards will be made for a maximum

period of three years each.

 

This announcement is not a Request for Proposals (RFP).  The RFP will

be issued on or about February 3, 1992.  Proposals will be due

approximately 90 days thereafter.  Requests for copies of the RFP may

be directed to:

 

Paul J. Duska, Contracting Officer

Contracts Management Branch, OGC

National Institute of Child Health and Human Development

Executive Plaza North, Room 610

900 Rockville Pike

Bethesda, MD  20892

FAX:  (301) 402-0915

 

.

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