EVALUATION OF THE TOXIC AND CARCINOGENIC POTENTIAL OF SODIUM NITRITEAND O-NITROTOLUENE ADMINISTERED ORALLY IN LABORATORY ANIMALS

 

NIH GUIDE, Volume 21, Number 3, Part II of II, January 24, 1992

 

RFP AVAILABLE:  NIH-ES-92-19

 

P.T. 34



Keywords:

  Toxicology 

  Cancer/Carcinogenesis 

  Dosage Forms+ 

 

National Institute of Environmental Health Sciences

 

The purpose of this contract is to evaluate the toxic and

carcinogenic potential of sodium nitrite and o-nitrotoluene

administered orally in laboratory animals.  The base contract award

will include work activities associated with bulk chemistry, dose

formulation and dose analysis developmental work, and health and

safety concerns.  The Government may, pending the availability of

funds, exercise options for:  a study of Cinnamaldehyde; a 13-week

study of cinnamaldehyde, a 104-week chronic study of cinnamaldehyde,

a 104-week chronic study of sodium nitrite, and a 104- week chronic

study of o-nitrotoluene.  Laboratory animals, that will be used in

these studies, are Fischer 344/N rats and B6C3F1 mice.  These studies

shall be conducted in accordance with the Food and Drug

Administration (FDA) Good Laboratory Practice Regulations as

specified in Part 58 "Good Laboratory Practices for Nonclinical

Laboratory Studies" (Federal Register, Friday, December 22, 1978,

Part II and any later interpretations published by the FDA).

 

Award of one cost-reimbursement, completion-type contract with an

estimated period of performance for the base contract of

approximately ten months on an open-competition basis is contemplated

as a result of this solicitation.  Exercise of all options under this

solicitation may result in a multi-year, cost-reimbursement type

contract with a total term of five years six months that would be

incrementally funded.  All responsible sources may submit a proposal

that will be considered by the Agency.  Expected release date of the

RFP is January 27, 1992, with proposals due March 12, 1992.

 

Requests should reference RFP NIH-ES-92-19 and be forwarded to:

 

Contracts and Procurement Management Branch, OM

National Institute of Environmental Health Sciences

ATTN:  Marilyn B. Whaley, Contract Specialist

79 T.W. Alexander Drive, 4401 Building, P.O. Box 12874

Research Triangle Park, NC  27709

Telephone:  (919) 541-5770

 

.

Return to 1992 Index

Return to NIH Guide Main Index

	Office of Extramural Research (OER)			National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892			Department of Health and Human Services (HHS)