EVALUATION OF THE TOXIC AND CARCINOGENIC POTENTIAL OF ISOPRENE,INDIUM PHOSPHIDE, AND GALLIUM ARSENIDE WHEN INHALED IN FISCHER 344/N

RATS AND B6C3F1 MICE

 

NIH GUIDE, Volume 21, Number 3, Part II of II, January 24, 1992

 

RFP AVAILABLE:  NIH-ES-92-17

 

P.T. 34



Keywords:

  Toxicology 

  Cancer/Carcinogenesis 

 

National Institute of Environmental Health Sciences

 

The purpose of this contract is to evaluate the toxic and

carcinogenic potential of isoprene, gallium arsenide, and indium

phosphide when inhaled in Fischer 344/N rats and B6C3F1 mice.  The

base contract award will include work activities associated with bulk

chemistry, generation and monitoring developmental work, and health

and safety concerns.  The Government may, pending the availability of

funds, exercise options for:  an inhalation study of glutaraldehyde,

a 104-week chronic study of glutaraldehyde, a 104- week chronic study

of isoprene; a 104-week chronic study of gallium arsenide; a 13-week

study of indium phosphide, and a 104-week chronic study of indium

phosphide.  These studies shall be conducted in accordance with the

Food and Drug Administration (FDA) Good Laboratory Practice

Regulations as specified in Part 58 "Good Laboratory Practices for

Nonclinical Laboratory Studies" (Federal Register, Friday, December

22, 1978, Part II and any later interpretations published by the

FDA).

 

Award of one cost-reimbursement, completion-type contract with an

estimated period of performance for the base contract of

approximately one year on an open competition basis is contemplated

as a result of this solicitation.  Exercise of all options under this

solicitation may result in a multi-year cost-reimbursement type

contract with a total term of four years nine months that would be

incrementally funded.  All responsible sources may submit a proposal

that will be considered by the Agency.  Expected release date of the

RFP is January 27, 1992, with proposals due March 12, 1992.

 

Requests should reference RFP NIH-ES-92-17 and be sent to:

 

Contracts and Procurement Management Branch, OM

National Institute of Environmental Health Sciences

ATTN:  Marilyn B. Whaley, Contract Specialist

79 T.W. Alexander Drive, 4401 Building

P.O. Box 12874

Research Triangle Park, NC  27709

Telephone:  (919) 541-5770

 

.


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