Notice Number: NOT-OD-20-048
Release Date: December 13, 2019
First Available Due Date: January 28, 2020
Expiration Date: January 26, 2021
PA-18-591: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
Office of Research on Women's Health (ORWH)
National Eye Institute (NEI)
National Heart, Lung, and Blood Institute (NHLBI)
National Human Genome Research Institute (NHGRI)
National Institute on Aging (NIA)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
National Institute on Deafness and Other Communication Disorders (NIDCD)
National Institute of Dental and Craniofacial Research (NIDCR)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institute on Drug Abuse (NIDA)
National Institute of Environmental Health Sciences (NIEHS)
National Institute of General Medical Sciences (NIGMS)
National Institute of Mental Health (NIMH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Institute of Nursing Research (NINR)
National Institute on Minority Health and Health Disparities (NIMHD)
National Library of Medicine (NLM)
National Center for Complementary and Integrative Health (NCCIH)
National Center for Advancing Translational Sciences (NCATS)
Sexual and Gender Minority Research Office (SGMRO)
Office of The Director, National Institutes of Health (OD)
National Cancer Institute (NCI)
National Institute of Arthritis and Musculoskeletal and Skin ( NIAMS ) New participating organization as of 06/082020 for due dates on/after 06/08/2020
The Office of Research on Women's Health (ORWH) announces the availability of administrative supplements to support research highlighting health disparities among women in the US who are underrepresented, understudied, and underreported (U3) in biomedical research. The proposed research must address at least one objective from the strategic goals 1, 2, or 3 of the 2019-2023 Trans-NIH Strategic Plan for Women's Health Research "Advancing Science for the Health of Women."
NIH encourages and supports biomedical research that serves the entirety of the population of women in the US. However, there is a disproportionate burden of disease that exists in a significant subpopulation of women, including racial and ethnic minorities, immigrants, those living in poverty, and those in both rural and urban areas. These subpopulations are diverse and are not mutually exclusive. Women and girls in these subpopulations bear a disproportionate burden of health risks and conditions compared to the general US population but are often underrepresented and understudied in clinical and biomedical research and underreported in surveillance data. Similarly, women with physical, intellectual, and developmental, and sensory disabilities also are often underrepresented in biomedical research. When women are not well represented in clinical research subsequent interventions may not be relevant to the health of women https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425923/
Understudied and underreported subpopulations represent an increasing percentage of the US population and bear a disproportionate burden of health risk, poorer health, and disease prevalence. In 2014 ORWH published "The Women of Color Health Data Book, 4th edition" (https://orwh.od.nih.gov/sites/orwh/files/docs/WoC-Databook-FINAL.pdf), which consists of US Government sourced, population-based health and disease data which highlights these health disparities. Additionally, women in a sexual minority (including but not limited to transgender and intersex women) are often underrepresented in biomedical research as well as in data reporting, failing unique opportunities to learn more about not only the differences among men and women, but also the effects of the hormonal milieu that differs from that expected based upon biologic sex alone.
The health of women is affected by a multitude of factors acting across the life course. The complex intersection of these internal (e.g., genetics) and external (e.g., social determinates) factors play a crucial role in the health status, disease presentations, and treatment responses of women as well as the effects of diseases and conditions on women's quality of life. Thus, consideration of a multidimensional framework (Schweinhart and Clayton, 2018) is needed to improve the quality of women's lives, reduce their disease burden across the life course, and address health disparities for populations of women at most considerable risk for certain diseases.
Interdisciplinary research initiatives integrating perspectives from multiple disciplines—as well as researchers with diverse skills, knowledge, and experiences—are crucial to capturing the complex interplay of various factors affecting the health of all women. Therefore, this NOSI encourages research on emerging topics that include collaborations across a range of disciplines including but not limited to economics, medical anthropology, psychology, sociology, and demography to address areas in the fuller context of women's lives and the underlying common root causes of poorer health outcomes.
Specific Areas of Research Interest
The NOSI will support projects that highlight common sources of disparities in women's health. The common pathways for the manifestations of ill health and disease, differential risk, risk exposure, resilience, morbidity, and mortality at the individual, community, and national levels are areas of particular research interest. This NOSI provides the following descriptions for the applicants to consider:
Only PDs/PIs of an active P01, P20, P30, P50, P60, P2C, S06, U10, U19, U2C, U54, UC2, UM2, R01, R15, R21, R24, R25, R33, R34, R35, RC4, S11, U01, UM1, UP5 award from NIH are eligible to apply. The PDs/PIs are encouraged to apply electronically.
PDs/PIs of the activity, as mentioned above, must also fulfill all the following mandatory requirements; otherwise, their applications will not be responsive for this NOSI.
Scientific Review Process
NIH program staff will conduct administrative reviews of submitted applications and will support the most meritorious applications submitted for consideration, pending availability of funds.
Scope of Support
Administrative supplements can be used to meet increased costs that are within the scope of the approved award, but that were unforeseen when the new or renewal application or grant progress report for non-competing continuation support was submitted. Applicants should propose research that, if successful, would contribute to a greater understanding of the health and wellbeing of underrepresented, understudied, unreported women in the US population.
It is strongly recommended that the applicant contact their respective program officers at the Institute supporting the parent award to confirm ahead of time that the supplement falls within the scope of the parent award.
Application and Submission Information
PA-18-591 - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
Please direct all inquiries to:
Rajasri Roy Ph.D., MPH
Office of Research on Women's Health (ORWH)