This Notice was RESCINDED on July 23, 2018, please see NOT-OD-18-197 that replaces it.


This Notice was RESCINDED on July 23, 2018, please see NOT-OD-18-197 that replaces it.

RESCINDED - NEW NIH POLICY ON SUBMISSION OF REVISED (AMENDED) APPLICATIONS NIH GUIDE, Volume 25, Number 19, June 14, 1996 (See update: NOT-97-011) P.T. 34 Keywords: Grants Administration/Policy+ National Institutes of Health Beginning with the October 1996 receipt date, the National Institutes of Health (NIH) will no longer consider any A3 or higher amendments to an application and, regardless of the number of amendments, the NIH will not accept a revised (amended) application that is submitted later than two years beyond the date of the receipt of the initial, unamended application. The new policy applies to all mechanisms. Recent NIH data indicate that amended applications constitute more than one third of all research project grant applications. The data also indicate that investigators who receive initial funding based on an amended application, whether for a new submission (Type 1) or a competing renewal (Type 2), experience a lower success rate in subsequent efforts to secure funding for a competing renewal application, and the probability of subsequent success in the competing renewal process diminishes with the number of amendments. We believe that after these three unsuccessful attempts at funding, it is preferable for all applicants to take a fresh start at their research plans. Therefore, the NIH has adopted a policy that limits the number of amendments to two. This limit allows principal investigators sufficient time to generate preliminary data if it is required by the reviewers, and to consider new findings in the area of research. INQUIRIES Questions or comments concerning this policy may be directed to the Director, Office of Extramural Research at

Weekly TOC for this Announcement
NIH Funding Opportunities and Notices

NIH Office of Extramural Research Logo
  Department of Health and Human Services (HHS) - Home Page Department of Health
and Human Services (HHS) - Government Made Easy
NIH... Turning Discovery Into Health®

Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.