Notice of Correction to Revise Application Due Dates for NOT-TR-19-001 Notice of Availability of Administrative Supplements for Microphysiological Systems Developers: Development of Tissue Chips to Model Nociception, Opioid Addiction and Overdose

Notice Number: NOT-TR-19-009

Key Dates
Release Date: October 24, 2018

Related Announcements
None

Issued by
National Center for Advancing Translational Sciences (NCATS)

Purpose

The purpose of this notice is to correct the due date for NOT-TR-19-001 Notice of Availability of Administrative Supplements for Microphysiological Systems Developers: Development of Tissue Chips to Model Nociception, Opioid Addiction and Overdose.

Currently Reads:

Submitting an Application

Applicants should begin their applications by stating: “This application is being submitted in response to NOT-TR-19-001". 

Through this Notice, NCATS will only consider submissions in which the Research Strategy does not exceed 6 pages and that include a summary or abstract of the funded parent award.

Projects should:

  • Appropriately model a nociception/addiction/overdose-relevant organ system to fit the objectives of the funding opportunity.
  • Utilize MPS that can be demonstrated to provide a better model than currently existing tissue models or other model systems.
  • Build up key resources and components for future development of better platforms to model pain-relevant pathways/outcomes, including the selection of appropriate cell sources from induced pluripotent stem cell (iPSC) sources or commercially available cell lines.
  • Include endpoints (molecular, electrophysiological, imaging, etc.) that can be demonstrated to correlate with clinical measures of nociception/addiction/overdose.
  • Adhere to milestones and an overall timeline to ensure completion of the project within the first phase of a parent biphasic grant or within the remaining timeframe of a monophasic grant.

Applications are due by 5:00 PM local time on October 26, 2019 and should be submitted per instructions in Part 2, Section IV. of "Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)" PA-18-591, with the following modifications:

Revised to Read:

Submitting an Application

Applicants should begin their applications by stating: “This application is being submitted in response to NOT-TR-19-001". 

Through this Notice, NCATS will only consider submissions in which the Research Strategy does not exceed 6 pages and that include a summary or abstract of the funded parent award.

Projects should:

  • Appropriately model a nociception/addiction/overdose-relevant organ system to fit the objectives of the funding opportunity.
  • Utilize MPS that can be demonstrated to provide a better model than currently existing tissue models or other model systems.
  • Build up key resources and components for future development of better platforms to model pain-relevant pathways/outcomes, including the selection of appropriate cell sources from induced pluripotent stem cell (iPSC) sources or commercially available cell lines.
  • Include endpoints (molecular, electrophysiological, imaging, etc.) that can be demonstrated to correlate with clinical measures of nociception/addiction/overdose.
  • Adhere to milestones and an overall timeline to ensure completion of the project within the first phase of a parent biphasic grant or within the remaining timeframe of a monophasic grant.

Applications are due by 5:00 PM local time on November 19, 2018 and should be submitted per instructions in Part 2, Section IV. of "Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)" PA-18-591, with the following modifications:

All other aspects of these FOAs remain unchanged.

Inquiries

Please direct all inquiries to:

Danilo Tagle, Ph.D.
National Center for Advancing Translational Sciences (NCATS)
Telephone: 301-594-8064
Email: danilo.tagle@nih.gov

Lucie Low, Ph.D.
National Center for Advancing Translational Sciences (NCATS)
Telephone: 301-594-7609
Email: lucie.low@nih.gov

Lili Portilla, M.P.A.
National Center for Advancing Translational Sciences (NCATS)
Telephone: 301-827-7170
Email: lili.portilla@nih.gov

Shannon Oden
National Center for Advancing Translational Sciences (NCATS)
Telephone: 301-594-3028
Email: shannon.oden@nih.gov