Notice of Modifications to PAR-15-173 "Pre-Application for Collaborative Innovation Award, CTSA Program (X02)" to Expand the List of High Priority Translational Research Opportunities

Notice Number: NOT-TR-16-004

Key Dates
Release Date:   December 16, 2015  

Related Announcements

Issued by
National Center for Advancing Translational Sciences (NCATS)


The purpose of this Notice is make modifications for PAR-15-173 to expand the list of high priority translational research opportunities. 

This FOA supports applications for innovative collaborative investigations (involving three or more CTSA sites) into improvements of the methods of translational research, at any step in the translational spectrum (T1-T4).  It is anticipated that the combined effort of three or more CTSA hubs in flexible networks will substantially enhance the effectiveness of the CTSA consortium to address high priority translational research questions.  PAR-15-173 therefore aims to support innovative and collaborative experimental translational research projects carried out in the CTSA consortium.  Below is an additional high priority translational research area suitable for this FOA:

Part 2. Section I. Funding Opportunity Description
The following text is added to Specific Objectives

  • Utilizing microphysiological systems (or organs on chips) in translational initiatives including drug discovery, novel mechanisms in disease models (including rare disease), refined and well-characterized iPSC tissues for TC systems, multi-organ system integration and personalized “you-on-a-Chip” technology.  Microphysiological systems are defined as devices containing scaffolding, mechanical factors (ex. perfusion, stretch) and multi-cellular tissues that recapitulate physiological environments. 


Please direct all inquiries to:

Philip J. Brooks, Ph.D.
National Center for Advancing Translational Sciences (NCATS)
Telephone: 301-443-0513