Notice of Intent to Publish a Funding Opportunity Announcement Trial Innovation Centers - TICs for the Clinical and Translational Science Award Network (U01)

Notice Number:


Key Dates

Release Date: December 19, 2014

Estimated Publication Date of Announcement: February 2015

First Estimated Application Due Date: June 2015

Earliest Estimated Award Date: February 2016

Earliest Estimated Start Date: February 2016

Related Announcements


Issued by

National Center for Advancing Translational Sciences (NCATS)


The National Center for Advancing Translational Sciences (NCATS) intends to complement and enhance the existing capabilities of the Clinical and Translational Science Award (CTSA) consortium by promoting greater capacity for the CTSA hubs to collaboratively serve as an expert network of innovation in the implementation of multi-site studies. To this end, NCATS intends to publish a Funding Opportunity Announcement (FOA) to solicit applications for Trial Innovation Centers (TICs). These centers will build on the results of ongoing CTSA consortium activities, and will facilitate the implementation of multi-site clinical trials by developing innovative approaches to increasing clinical trial efficiency and effectiveness, and providing expert, streamlined clinical coordination so that the CTSA consortium can catalyze translation.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and establish approaches to perform these duties.

The FOA is expected to be published in winter 2015 with an expected application due date in spring 2015.

This FOA will utilize the U01 activity code. Details of the planned FOA are provided below.

Research Initiative Details

This Notice encourages investigators with expertise, track record, and insights into the area of multi-site study coordination to begin to consider applying for this forthcoming FOA.

Multi-site clinical trials are a critical step in bringing new treatments to patients. However, launching and conducting large trials is currently inefficient, preventing facile translation of discoveries into patient benefit. To catalyze innovation in the process, NCATS intends to launch TICs that provide customized trial support including but not limited to the realization of central Institutional Review Boards (cIRBs), master trial agreements, streamlined organization, communications and oversight. The TICs will support quality and efficiency in the conduct of multi-site studies, and thus accelerate the translation from discoveries to health benefits.



Please direct all inquiries to:

Todd M. Wilson, D.O.
National Center for Advancing Translational Sciences (NCATS)
Telephone: 301-435-0768