AVAILABILITY OF HUMAN PANCREATIC ISLETS FOR NON-CLINICAL RESEARCH THROUGH THE ISLET CELL RESOURCE (ICR) CENTERS RELEASE DATE: August 27, 2003 NOTICE: NOT-RR-03-009 National Center for Research Resources (NCRR) National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) Patients having Type I diabetes mellitus have achieved long-term independence from exogenous insulin after receiving human pancreatic islet cell transplants. To expand upon this observation, 10 Islet Cell Resource Centers (ICRs) were established in September 2001 as regional resources to provide clinical grade human islets to investigators engaged in islet transplantation protocols throughout the country and to optimize the procedures used to obtain such islets. Each ICR possesses significant expertise in human pancreatic islet isolation and operates a processing facility that is compliant with FDA guidelines for current Good Manufacturing Practice (cGMP). The ICR consortium will now also accept requests for islets to be used in non-clinical research. A sub-committee of the ICR Steering Committee will review these applications and those receiving a favorable evaluation can suggest which ICR should generate these islets. Islets will be provided to investigators based on their availability and the priority assigned to the request. Investigators will be charged $0.10 per islet equivalent, the sum being payable to the ICR provider. Islets should be requested through the Administrative and Bioinformatics Coordinating Center (ABCC), which provides the administrative, informatics and statistical support for the ICR consortium. Application forms and additional information are available at http://icr.coh.org or by contacting: Rebecca Nelson, Ph.D., Project Administrator Administrative and Bioinformatics Coordinating Center Division of Information Sciences City of Hope/Beckman Research Institute 1500 East Duarte Road Duarte, CA 91010-3000 Tel: 626-359-8111 x64040 Fax: 626-471-7106 rnelson@coh.org Programmatic information is available from: Richard A. Knazek, M.D. Division of Clinical Research National Center for Research Resources Democracy One, Room 910 6701 Democracy Blvd. Bethesda, Maryland 20892 Phone 301-435-0792 FAX 301-480-3661 knazekr@mail.nih.gov Thomas L. Eggerman, M.D., Ph.D. Director, Islet Transplantation Program Division of Diabetes, Endocrinology and Metabolic Diseases National Institute of Diabetes, Digestive and Kidney Diseases Democracy Two, Rm 697 6707 Democracy Blvd. Bethesda, MD 20892-5460 Phone 301-594-8813 FAX 301-480-3503 eggermant@extra.niddk.nih.gov
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