Notice of Intent to Publish a Funding Opportunity for the NIH Common Fund Human Virome Program: Characterization of functional interactions between viruses and human and microbial hosts (U01 Clinical Trial Not Allowed)
Notice Number:

Key Dates

Release Date:
June 07, 2023
Estimated Publication Date of Notice of Funding Opportunity :
August 04, 2023
First Estimated Application Due Date:
November 15, 2023
Earliest Estimated Award Date:
July 31, 2024
Earliest Estimated Start Date:
July 31, 2024
Related Announcements
  • June 7, 2023 - Notice of Intent to Publish a Funding Opportunity for the NIH Common Fund Human Virome Program: Developing Novel and Innovative Tools to Interrogate and Annotate the Human Virome (U01 Clinical Trial Not Allowed). See NOT-RM-23-014
  • June 7, 2023 - Notice of Intent to Publish a Funding Opportunity for the NIH Common Fund Human Virome Program: Consortium Organization and Data Collaboration Center (CODCC) for the Human Virome Program (HVP) (U24 Clinical Trial Not Allowed). See NOT-RM-23-016
  • June 7, 2023 - Notice of Intent to Publish a Funding Opportunity for the NIH Common Fund Human Virome Program: Characterize the Human Virome in Longitudinal, Diverse Cohorts Across the Lifespan (U54 Clinical Trial Not Allowed). See NOT-RM-23-017
Issued by

Office of Strategic Coordination (Common Fund)


The Office of Strategic Coordination (Common Fund) intends to publish a funding opportunity to support Functional Interaction Studies grants for the NIH Common Fund supported Human Virome Program (HVP).  More information on the HVP can be found at

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and develop their approaches. The funding opportunity is expected to be published in August 2023 with an expected application due date at least 60 days after publication. No foreign applications will be allowed.

The funding opportunity will use the cooperative agreement U01 mechanism for “Research Project Cooperative Agreement (Clinical Trial Not Allowed)” Details of the planned funding opportunity are provided below.

Research Initiative Details

The NIH Common Fund HVP’s overall goal is to establish a research consortium to extensively characterize the human virome and create tools, models, methods that will enable in-depth study of its variation in relation to host factors and its influence on health and disease. It is anticipated that exploration of the human virome will provide insights into the health effects of tri-kingdom interactions (host-microbiome-virome) occurring within the human body and inform future studies examining novel disease connections. For the purposes of the NIH Common Fund HVP, members of the virome are viruses that establish a population within the human body (i.e., not transient) either as latent, persistent, integrated, or lytic in the human host itself or in any of the prokaryotic or eukaryotic members of the microbiome in the human host. Despite recent technological advances, significant challenges remain that have hindered progress, including detection sensitivity, contaminant removal, scalability, and sample adequacy.

The new funding opportunity will support HVP Functional Interaction Studies grants to join the HVP consortium. The goal of this initiative is to study interactions between the virome, human host, and microbiota and their functional implications on health and disease.

The selected HVP Functional Interaction Studies projects will work collaboratively with each other and other components of the HVP consortium to develop and implement improved virome functional studies.

Funding for the HVP will come from the NIH Common Fund, which supports cross-cutting programs expected to have exceptionally high impact. All Common Fund initiatives invite investigators to develop bold, innovative, and high-risk approaches to address problems that may seem intractable or to seize new opportunities that offer the potential for rapid progress.

Funding Information (subject to availability of funds)

Funding Information

Estimated Total Funding


Expected Number of Awards
Estimated Award Ceiling


Primary Assistance Listing Number(s)


Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Regional Organization

Applications are not being solicited at this time. 


Please direct all inquiries to:

Hye-Sook Kim, Ph.D.
National Center for Complementary and Integrative Health (NCCIH)