February 27, 2023
PAR-23-035: Discovery of the Genetic Basis of Childhood Cancers and of Structural Birth Defects: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed)
Office of Strategic Coordination (Common Fund)
The purpose of NIH Common Fund opportunity announcement PAR-23-035: Discovery of the Genetic Basis of Childhood Cancers and of Structural Birth Defects: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed) is to invite applications to submit samples from pediatric cohorts for whole genome sequencing at a Kids First Program-supported sequencing center. This announcement is a Common Fund initiative (Common Fund) through the NIH Office of the Director, Office of Strategic Coordination (https://dpcpsi.nih.gov/). All NIH Institutes and Centers participate in Common Fund initiatives. This initiative will be administered by a trans-NIH team led by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
Applicants are encouraged to propose sequencing of existing pediatric cancer or structural birth defect cohorts to elucidate the genetic contribution (somatic and/or germline) to childhood cancers, to investigate the genetic etiology of structural birth defects, to study the molecular basis of the associations between birth defects and increased cancer risk, or to expand the range of pediatric disorders included within the Kids First Data Resource. The program will accept applications that propose whole genome, exome, and transcriptome sequencing, as well as epigenomic assays of tumor or affected tissue, when justified. Applicants are encouraged to propose cohorts of underrepresented racial and ethnic groups or to increase racial and ethnic representation of existing Kids First Program projects. These data, and associated clinical and phenotypic data, will become part of the Kids First Data Resource Center for sharing with the research community.
The NIH Common Fund will host a pre-application webinar to provide information and respond to questions from prospective applicants who plan to submit applications to PAR-23-035 on March 3, 2023, from 12:00 pm – 1:00 pm Eastern Time (ET). NIH program, grants management, and review staff will discuss the overall scope and intent of this opportunity, application guidelines, and review process. NIH staff will not provide comments on specific ideas or plans for individual research applications during the webinar.
Participation in the webinar, although encouraged, is optional and is not required for the submission of an application.
The webinar will be hosted through Zoom
Date: March 3, 2023
Time: 12:00 – 1:00 pm (ET)
To join the webinar, pre-registration is required at: https://nih.zoomgov.com/meeting/register/vJItd-qsrT8jGpqU3mq-MLYQ-Q8ItvjNd6E
After the webinar, webinar slides and a recording will be posted on the Kids First website.
Marcia Fournier, Ph.D.
Member of Working Group Leadership
Gabriella Miller Kids First Pediatric Research Program