Department of Health
and Human Services (HHS)
and Human Services (HHS)
August 19, 2021
OTA-21-012 - The Human BioMolecular Atlas Program (HuBMAP) Integration, Visualization & Engagement (HIVE) Collaboratory (OT2)
Office of Strategic Coordination (Common Fund)
This Notice announces the publication of a new Research Opportunity Announcement (ROA), Human Biomolecular Atlas Program (HuBMAP), Integration, Visualization & Engagement (HIVE) Collaboratory and the key dates for submitting Letters of Intent (LOI) and full proposals. The ROA was released on the NIH Common Fund website.
HIVE Letter of Intent (LOI) Due Date (Required): 1 Oct 2021
Full Proposal Deadline(s) (due by 5 p.m. submitter's local time): 3 Dec 2021
The Human BioMolecular Atlas Program (HuBMAP) seeks to catalyze development of atlases of the human body at high resolution to transform our understanding of tissue organization and function. In this context, the role of the HuBMAP Integration, Visualization & Engagement (HIVE) Collaboratory is to extend and expand the computational tools and framework built in the first 4 years of HuBMAP. As such the HIVE will: 1) manage the data generated by the HuBMAP Consortium, 2) coordinate internal and external Consortium activities, 3) develop novel tools for visualizing, searching, and modelling data and 4) build an atlas of tissue maps.
The HIVE will be composed of projects funded in three component areas all of which are expected to work closely together to act as the unified backbone for HuBMAP. These components are: 1) an Infrastructure Component (IC); 2) Mapping Component (MC); and 3) Tools Component (TC). The IC would be responsible for maintaining, optimizing, and scaling a reliable, accessible infrastructure for archiving and analysis of data generated initially by HuBMAP and later by the wider research community. The MC is to develop the framework for spatially mapping the data in the context of the human body, organ(s), and regions, as well as implementing novel methods to build tissue level maps that can be stitched together using multi-modal data. While the TC will focus on creating and/or using community standard methods for data analysis, processing, interpretation, and visualization of HuBMAP data. Each component will also have joint responsibilities regarding outreach and community engagement, ensuring data and metadata integrity and formatting. Likewise adherence to FAIR standards, community and internal standards, and HuBMAP consortium policies will be shared responsibilities.
An application may propose to one, some, or all component areas. However, when applying to multiple components, a coordinated set of separate applications, each describing a separate component but with a common vision should be included. This ROA requires a Plan for Enhancing Diverse Perspectives (PEDP) as part of the application. Applicants are strongly encouraged to read the ROA instructions carefully and view the available?PEDP guidance material
Prospective applicants are strongly encouraged to contact NIH staff (HuBMAP@mail.nih.gov) with questions regarding the existing solutions (HuBMAP data portal) including data ingest, standards, data portal, website, and other solutions created by the awardees in HuBMAP and HIVE during the scale-up phase.
A Technical Assistance teleconference will be held for potential applicants from 2-3pm Eastern Time on Friday August 27, 2021. Dial in information for the call is posted on the HuBMAP website and slides will be made available on the website for those unable to attend.
NIH especially encourages groups and investigators who have not been supported by the HuBMAP program to date to apply.
Award Information
The planned budget for this effort is approximately $40 million over a 4-year period. NIH anticipates making 5-7 HIVE awards. However, NIH Common Fund procedures and OT mechanisms allow for significant flexibilities and adjustments as may be necessary to pursue catalytic and transformative initiatives. Award levels may increase or decrease over time based on programmatic needs, funding availability, and recipient performance. In addition to the due date given above, additional due dates may be made available in the future and will be announced by posting on the program website.
Eligibility Information
Who May Submit Proposals:
Successful applicants may or may not have received NIH funding in the past. All entities public and private, small or large, for-profit or not-for-profit, are eligible to apply. Unaffiliated individuals who are U.S. citizens are also eligible to apply.
Who May Serve as PI:
There are no restrictions or limits.
Limit on Number of Proposals per Organization:
There are no restrictions or limits.
Limit on Number of Proposals per PI or Co-PI:
There are no restrictions or limits.
Eligible Organizations:
Higher Education Institutions
The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
Nonprofits Other Than Institutions of Higher Education
For-Profit Organizations
Governments
Other
Foreign Institutions
Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Proposal Limit:
Proposals submitted in response to this ROA may not duplicate or be substantially similar to other proposals concurrently under consideration by other programs or study sections of the NIH or other federal agencies. Duplicate or substantially similar proposals will not be reviewed.
Budgetary Information Cost Sharing Requirements:
Inclusion of voluntary committed cost sharing is prohibited.
Indirect Cost (F&A) Limitations:
Not Applicable
Other Budgetary Limitations:Other budgetary limitations apply. Please see the full text of this ROA for further information,https://commonfund.nih.gov/sites/default/files/HuBMAP-HIVE-ROA-v1-508.pdf.
Email: HUBMAP@mail.nih.gov