Notice Announcing the Human BioMolecular Atlas Program (HuBMAP) Integration, Visualization & Engagement (HIVE) Collaboratory (OT2) Other Transaction Opportunity Announcement
Notice Number:

Key Dates

Release Date:

August 19, 2021

Related Announcements

OTA-21-012 - The Human BioMolecular Atlas Program (HuBMAP) Integration, Visualization & Engagement (HIVE) Collaboratory (OT2)

Issued by

Office of Strategic Coordination (Common Fund)


This Notice announces the publication of a new Research Opportunity Announcement (ROA), Human Biomolecular Atlas Program (HuBMAP), Integration, Visualization & Engagement (HIVE) Collaboratory and the key dates for submitting Letters of Intent (LOI) and full proposals. The ROA was released on the NIH Common Fund website.

HIVE Letter of Intent (LOI) Due Date (Required): 1 Oct 2021

Full Proposal Deadline(s) (due by 5 p.m. submitter's local time): 3 Dec 2021

The Human BioMolecular Atlas Program (HuBMAP) seeks to catalyze development of atlases of the human body at high resolution to transform our understanding of tissue organization and function. In this context, the role of the HuBMAP Integration, Visualization & Engagement (HIVE) Collaboratory is to extend and expand the computational tools and framework built in the first 4 years of HuBMAP. As such the HIVE will: 1) manage the data generated by the HuBMAP Consortium, 2) coordinate internal and external Consortium activities, 3) develop novel tools for visualizing, searching, and modelling data and 4) build an atlas of tissue maps.

The HIVE will be composed of projects funded in three component areas all of which are expected to work closely together to act as the unified backbone for HuBMAP. These components are: 1) an Infrastructure Component (IC); 2) Mapping Component (MC); and 3) Tools Component (TC). The IC would be responsible for maintaining, optimizing, and scaling a reliable, accessible infrastructure for archiving and analysis of data generated initially by HuBMAP and later by the wider research community. The MC is to develop the framework for spatially mapping the data in the context of the human body, organ(s), and regions, as well as implementing novel methods to build tissue level maps that can be stitched together using multi-modal data. While the TC will focus on creating and/or using community standard methods for data analysis, processing, interpretation, and visualization of HuBMAP data. Each component will also have joint responsibilities regarding outreach and community engagement, ensuring data and metadata integrity and formatting. Likewise adherence to FAIR standards, community and internal standards, and HuBMAP consortium policies will be shared responsibilities.

An application may propose to one, some, or all component areas. However, when applying to multiple components, a coordinated set of separate applications, each describing a separate component but with a common vision should be included. This ROA requires a Plan for Enhancing Diverse Perspectives (PEDP) as part of the application. Applicants are strongly encouraged to read the ROA instructions carefully and view the available?PEDP guidance material

Prospective applicants are strongly encouraged to contact NIH staff ( with questions regarding the existing solutions (HuBMAP data portal) including data ingest, standards, data portal, website, and other solutions created by the awardees in HuBMAP and HIVE during the scale-up phase.

A Technical Assistance teleconference will be held for potential applicants from 2-3pm Eastern Time on Friday August 27, 2021. Dial in information for the call is posted on the HuBMAP website and slides will be made available on the website for those unable to attend.

NIH especially encourages groups and investigators who have not been supported by the HuBMAP program to date to apply.

Award Information

The planned budget for this effort is approximately $40 million over a 4-year period. NIH anticipates making 5-7 HIVE awards. However, NIH Common Fund procedures and OT mechanisms allow for significant flexibilities and adjustments as may be necessary to pursue catalytic and transformative initiatives. Award levels may increase or decrease over time based on programmatic needs, funding availability, and recipient performance. In addition to the due date given above, additional due dates may be made available in the future and will be announced by posting on the program website.

Eligibility Information

Who May Submit Proposals:

Successful applicants may or may not have received NIH funding in the past. All entities public and private, small or large, for-profit or not-for-profit, are eligible to apply. Unaffiliated individuals who are U.S. citizens are also eligible to apply.

Who May Serve as PI:

There are no restrictions or limits.

Limit on Number of Proposals per Organization:

There are no restrictions or limits.

Limit on Number of Proposals per PI or Co-PI:

There are no restrictions or limits.

Eligible Organizations:

Higher Education Institutions

  • Public/State Controlled Institutions of Higher Education
  • Private Institutions of Higher Education

The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:

  • Hispanic-serving Institutions
  • Historically Black Colleges and Universities (HBCUs)
  • Tribally Controlled Colleges and Universities (TCCUs)
  • Alaska Native and Native Hawaiian Serving Institutions
  • Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)

Nonprofits Other Than Institutions of Higher Education

  • Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
  • Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)

For-Profit Organizations

  • Small Businesses
  • For-Profit Organizations (Other than Small Businesses)


  • State Governments
  • County Governments
  • City or Township Governments
  • Special District Governments
  • Indian/Native American Tribal Governments (Federally Recognized)
  • Indian/Native American Tribal Governments (Other than Federally Recognized)
  • Eligible Agencies of the Federal Government
  • U.S. Territory or Possession


  • Independent School Districts
  • Public Housing Authorities/Indian Housing Authorities
  • Native American Tribal Organizations (other than Federally recognized tribal governments)
  • Faith-based or Community-based Organizations
  • Regional Organizations

Foreign Institutions

Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Proposal Limit:

Proposals submitted in response to this ROA may not duplicate or be substantially similar to other proposals concurrently under consideration by other programs or study sections of the NIH or other federal agencies. Duplicate or substantially similar proposals will not be reviewed.

Budgetary Information Cost Sharing Requirements:

Inclusion of voluntary committed cost sharing is prohibited.

Indirect Cost (F&A) Limitations:

Not Applicable

Other Budgetary Limitations:Other budgetary limitations apply. Please see the full text of this ROA for further information,


Please direct all inquiries to:


Weekly TOC for this Announcement
NIH Funding Opportunities and Notices