Key Dates

NOT-RM-21-001 - Notice of Intent to Publish a Funding Opportunity Announcement for the NIH Common Fund Nutrition for Precision Health, powered by the All of Us Research Program: Artificial Intelligence for Multimodal Data Modeling and Bioinformatics Center (U54 Clinical Trial Not Allowed)

NOT-RM-21-003 - Notice of Intent to Publish a Funding Opportunity Announcement for the NIH Common Fund Nutrition for Precision Health, powered by the All of Us Research Program: Microbiome and Metagenomics Center(U24 Clinical Trial Not Allowed)

NOT-RM-21-006 - Notice of Intent to Publish a Funding Opportunity Announcement for the NIH Common Fund Nutrition for Precision Health, powered by the All of Us Research Program: Dietary Assessment Center (U24 Clinical Trial Optional)

NOT-RM-21-007 - Notice of Intent to Publish a Funding Opportunity Announcement for the NIH Common Fund Nutrition for Precision Health, powered by the All of Us Research Program: Clinical Centers (UG1 Clinical Trial Required)

NOT-RM-21-008 - Notice of Intent to Publish a Funding Opportunity Announcement for Nutrition for Precision Health, powered by the All of Us Research Program: Research Coordinating Center (U24 Clinical Trial Not Allowed)

Office of Strategic Coordination (Common Fund)

The Office of Strategic Coordination (Common Fund) intends to publish a funding opportunity announcement (FOA) to support one Metabolomics and Clinical Assays Center for the NIH Common Fund supported Nutrition for Precision Health, powered by the All of Us Research Program. Collaborative teams combining expertise in large scale targeted and non-targeted metabolomic profiling and clinical assays from multiple human biospecimen types will be crucial to the success of the studies.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and develop their approaches. The funding opportunity is expected to be published in January 2021 with an expected application due date at least 60 days after publication. No foreign applications will be allowed.

The FOA will utilize the cooperative agreement U24 mechanism for “Resource Related Research Projects-- Cooperative Agreements.” Details of the planned FOA are provided below.

Rationale. Research is needed to provide more precise and dynamic nutritional recommendations than currently possible through population-wide guidance. This in turn will facilitate a deeper understanding of how human biological systems and molecular pathways interact with or mediate the relationships among dietary patterns, environmental, social, and behavioral factors to influence health status. Through advances in -omic technologies and mobile devices—combined with the large and diverse participant sample and existing infrastructure of the All of Us Research Program, innovations in artificial intelligence, machine learning, computational and mathematical modeling of complex biological systems—an unprecedented opportunity exists currently to predict dietary responses and to design targeted dietary interventions aimed at improving health and quality of life.
 

Nutrition for Precision Health. The goal of the Nutrition for Precision Health powered by the All of Us Research Program consortium (referred to as “Nutrition for Precision Health” in this document) is to develop algorithms that predict individual responses to foods and dietary patterns. Nutrition for Precision Health will take advantage of multiple recent advances in biomedical science to generate data and develop predictive nutrition algorithms to help individuals and their health care providers create healthy diet plans. These advances include progress in nutrition science and our understanding of the human microbiome, increased use of artificial intelligence (AI) in the biomedical sciences, as well as the infrastructure and large, diverse cohort of the All of Us Research Program.

The new funding opportunity will support one Metabolomics and Clinical Assays Center to (1) generate targeted and non-targeted metabolite profiles and (2) perform or facilitate clinical assays from blood, urine, and stool biospecimens. The center should be able to provide broad coverage of the metabolome encompassing diverse metabolic pathways using appropriate platforms/technologies. It is expected that the coverage would encompass host, microbiome and food/component metabolite pathways as appropriate.

Funding for Nutrition for Precision Health will come from the NIH Common Fund, which supports cross-cutting programs expected to have exceptionally high impact. All Common Fund initiatives invite investigators to develop bold, innovative, and high-risk approaches to address problems that may seem intractable or to seize new opportunities that offer the potential for rapid progress. Nutrition for Precision Health will be embedded in the All of Us Research Program (allofus.nih.gov). The All of Us Research Program is part of an effort to advance individualized health care by enrolling one million or more participants to share their health data over at least 10 years. Nutrition for Precision Health will be guided by the core values (https://allofus.nih.gov/about/core-values) of the All of Us Research Program.

Applications are not being solicited at this time. 

Please direct all inquiries to:

Pothur R. Srinivas, Ph.D., M.P.H.
National Cancer Institute (NCI)
240-276-7620
srinivap@mail.nih.gov