Notice Number: NOT-RM-20-003
Release Date: December 19, 2019
First Available Due Date: February 11, 2020
Expiration Date: April 01, 2020
PA-18-591 "Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)"
Office of Strategic Coordination (Common Fund)
Glycans are saccharides that can be attached to a wide variety of biological molecules to augment their function. They play important roles in virtually all biological processes including early development, immune regulation, disease processes, and vaccine development. Often, glycans are the predominant molecule on the cell surface and serve as the first point of contact between cells, the extracellular matrix and pathogens. Although carbohydrates play important roles in both normal and disease processes, their complexity presents challenges to their study by most biomedical researchers.
To address these challenges, the NIH Common Fund Glycoscience Program (CF-GSP) was started in 2015. The program supports the development of methodologies, tools, and resources to simplify and expand the synthesis of large libraries of glycans; for glycan identification, tracking, manipulation, and functional analysis; and informatics to integrate gene, protein, and glycan datasets. Access to robust glycan libraries and tools to study N- and O-glycosylation, proteoglycans, polysaccharides, and glycolipids are expected to facilitate studies of the roles these molecules play in normal cellular processes and in disease.
Both the program’s resources and the tools being produced by the CF-GSP’s investigators are available to all NIH-funded investigators as well as the broader scientific community for exploration of the roles of carbohydrates in normal and disease processes. Chemical standards and reference data developed by investigators in the Glycoscience Program are freely available and can be found here: https://commonfund.nih.gov/Glycoscience/programresources
In addition, NIH-funded investigators are encouraged to test and adopt the many tools and technologies being developed by the CF-GSP for use in their own research programs. https://commonfund.nih.gov/Glycoscience/fundedresearch
To encourage broad adoption of CF-GSP tools/technologies, the Common Fund will support administrative supplements to NIH-supported investigators who are NOT part of the Glycoscience program and NOT established glycoscientists. These will be one-year administrative supplements to existing NIH awards for:
To be eligible, the parent award must be able to receive funds in FY2020 (Oct 1, 2019- Sept. 30, 2020) and not be in a no-cost extension period at the time of the award. One-time supplement budget requests cannot exceed $100,000/year direct costs. It is anticipated that 3-5 awards will be made, subject to availability of funds in FY2020.
Eligible Individuals (Program Director/Principal Investigator)
Individual(s) must hold an active grant or cooperative agreement that can be supplemented. For supplements to parent awards that include multiple PDs/PIs, a single supplement may be requested (for use by any or all of the PDs/PIs in accordance with the existing leadership plan) and submitted by the awardee institution of the parent award.
Description of circumstances for which administrative supplements are available.
Application and Submission Information
Applications for this initiative must be submitted using the following opportunity or its subsequent reissued equivalent.
Applicants are strongly encouraged to notify the program contact at the Institute or Center supporting the parent award to:
Each IC will conduct administrative reviews of applications submitted to their IC separately. The most meritorious applications submitted for consideration will be supported based upon availability of funds
Please direct all inquiries to:
Karl Krueger, Ph.D.
National Cancer Institute (NCI)