Notice Number: NOT-RM-19-012
Release Date: July 15, 2019
First Available Due Date: August 15, 2019
Expiration Date: August 16, 2019
Office of Strategic Coordination (Common Fund)
Glycans are saccharides that can be attached to a wide variety of biological molecules to augment their function. They play important roles in virtually all biological processes including early development, immune regulation, disease processes, and vaccine development. Often, glycans are the predominant molecule on the cell surface and serve as the first point of contact between cells, the extracellular matrix and pathogens. Although carbohydrates play important roles in both normal and disease processes, their complexity presents challenges to their study by most biomedical researchers.
To address these challenges, the NIH Common Fund Glycoscience Program (CF-GSP) was started in 2015. The program supports the development of methodologies, tools, and resources to simplify and expand the synthesis of large libraries of glycans; for glycan identification, tracking, manipulation, and functional analysis; and informatics to integrate gene, protein, and glycan datasets. Access to robust glycan libraries and tools to study N- and O-glycosylation, proteoglycans, polysaccharides, and glycolipids are expected to facilitate studies of the roles these molecules play in normal cellular processes and in disease.
Both the program’s resources and the tools being produced by the CF-GSP’s investigators are available to all NIH funded investigators as well as the broader scientific community for exploration of the roles of carbohydrates in normal and disease processes. Chemical standards and reference data developed by investigators in the Glycoscience Program are freely available and can be found here: https://commonfund.nih.gov/Glycoscience/programresources
In addition, NIH funded investigators are encouraged to Beta test/adapt the many tools and technologies being developed by the CF-GSP for use in their own research programs. https://commonfund.nih.gov/Glycoscience/fundedresearch
To encourage broad adoption of CF-GSP tools/technologies, the Common Fund will support administrative supplements to NIH-supported investigators who are NOT part of the Glycoscience program and NOT established glycoscientists. These will be one-year administrative supplements to existing NIH awards for:
Application and Submission Information
To be eligible, the parent award must be able to receive funds in FY19 (Oct. 1, 2018- Sept. 30, 2019) and not be in a no-cost extension period at the time of the award.
One-time supplement budget requests cannot exceed $100,000/year direct costs. It is anticipated that 3-5 awards will be made, subject to availability of funds in FY2019.
Eligible Individuals (Program Director/Principal Investigator)
Individual(s) must hold an active grant or cooperative agreement that can be supplemented. For supplements to parent awards that include multiple PDs/PIs, a single supplement may be requested (for use by any or all of the PDs/PIs in accordance with the existing leadership plan) and submitted by the awardee institution of the parent award.
Supplements to Grants/Cooperative Agreements:
Applications for this initiative must be submitted using PA-18-591 - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional) or its subsequent reissued equivalent.
All instructions in the SF424 (R&R) Application Guide and PA-18-591 must be followed, with the following additions:
Administrative Evaluation Process
Each IC will conduct administrative reviews of applications submitted to their IC separately. The most meritorious applications submitted for consideration will be supported based upon availability of funds.
1. Is the work proposed within the scope of the active award?
2. Does the work proposed address one of the components listed under the IC-specific research objectives?
3. Is there a collaboration between the non-glycoscience investigator and the CF-GSP glycoscience investigator that will lead to the beta testing/adoption of a CF-GSP tool and/or technology?
4. Does the work proposed have scientific merit?
5. Is the work likely to stimulate additional understanding of glycoscience mechanisms?
It is strongly recommended that the applicants contact their respective program officers at the Institute supporting the parent award to:
Investigators planning to submit an application in response to this NOSI are strongly encouraged to contact and discuss their proposed research/aims with the CF-GSP contact listed on this NOSI in advance of the grant receipt date.
Following submission, applicants are strongly encouraged to notify the program contact at the IC supporting the parent award that a request has been submitted in response to this FOA in order to facilitate efficient processing of the request.
Please direct all inquiries to:
Pamela Marino, Ph.D.
National Institute of General Medical Sciences (NIGMS)