Notice Number: NOT-RM-19-009
Release Date: July 01, 2019
First Available Due Date: July 29, 2019
Expiration Date: July 30, 2019.
Office of Strategic Coordination (Common Fund)
The NIH Common Fund has generated several valuable and widely available data sets by multiple programs. The purpose of this Notice is to announce the availability of administrative supplements to demonstrate use of selected Common Fund data sets, including generating hypotheses and catalyzing discoveries. Supplement recipients are also asked to provide feedback on utility of the Common Fund data resources.
Since its initial inception as the NIH Roadmap for Biomedical Research, the NIH Common Fund has supported dozens of transformative research programs that generated new technologies, methods, and data. Many of these programs generated rich public data sets containing a variety of multi-dimensional molecular and phenotypic data from several organisms including mouse and human. As various Common Fund data resources have become available, investigators frequently state that they are unaware of the data and/or of the relevance that the data may have for their research interests. In addition, some report difficulty using or exploring the data because the data portals are non-intuitive to use and/or the data are otherwise difficult to navigate. To maximize the impact of these data and engage a broader community of end-users for wider adoption of these data sets and to obtain feedback from supplement recipients to enhance the data portals, the Common Fund plans to support administrative supplements encouraging the use of Common Fund data sets. Supplements are intended to enable novel and compelling biological questions to be formulated and addressed, and/or to generate cross-cutting hypotheses for future research.
The Common Fund seeks to fund analyses and enhance utility of existing Common Fund data sets to uncover potential molecular mechanisms driving various diseases and to generate novel hypotheses for further testing. Investigators are encouraged to utilize various approaches including but not limited to systems approaches incorporating computational modeling to bring together high throughput genotype and phenotype data sets. Because information regarding the user experience could help NIH improve its data resources, it is expected that NIH will receive feedback from awardees on usability and utility of data sets and public data portals, which the awardees can provide in their progress reports.
The established Common Fund data sets listed below are well-poised for increased community use. Applicants must propose to use at least one data set from the following list, although they can propose to use other data sets as well. While integration across multiple data sets is encouraged, it is not required.
Examples of potential research topics include, but are not limited to, the following:
To be eligible, the parent award must be able to receive funds in FY19 (Oct. 1, 2018-Sept. 30, 2019) and not be in a no-cost extension period at the time of the award.
Supplement budget requests cannot exceed $200,000/year direct costs exclusive of Facilities and Administrative costs on sub-awards. Budgets may not exceed the total direct costs of the current parent award. Requests must reflect the actual needs of the proposed project. Requests may be only for one year of support. Modular and categorical budgets are permitted. It is anticipated that 10-15 awards will be made, subject to availability of funds.
Eligible Individuals (Program Director/Principal Investigator)
Individual(s) must hold an active grant or cooperative agreement. For supplements to parent awards that include multiple PDs/PIs, the supplement may be requested by any or all of the PDs/PIs (in accordance with the existing leadership plan) and submitted by the awardee institution of the parent award. All instructions for the Parent Announcement must be followed.
Supplements to Grants/Cooperative Agreements:
For administrative supplement to grants and cooperative agreements, supplement requests must be submitted in accordance with the parent program announcement: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional) PA-18-591.
Applicants should begin the supplement application abstract by stating “This application is being submitted in response to NOT-RM-19-009”
Scientific Review Process
The Office of Strategic Coordination (OSC) will conduct administrative reviews of submitted applications and will support the most meritorious applications submitted for consideration, pending availability of funds.
1. Is the work proposed within the scope of the parent award?
2. Will the work proposed demonstrate or enhance utility of Common Fund data sets?
3. Does the work proposed have high scientific merit?
4. Is the work likely to generate hypotheses which could lead to additional studies in the future?
5. Does the proposed work broaden the end-user community and/or encourage new users?
Application and Submission Information:
It is strongly recommended that the applicants contact their respective program officers at the Institute supporting the parent award to:
Investigators planning to submit an application in response to this NOSI are strongly encouraged to contact and discuss their proposed research/aims with the OSC contact listed on this NOSI well in advance of the grant receipt date.
Following submission, applicants are strongly encouraged to notify the program contact at the IC supporting the parent award that a request has been submitted in response to this FOA in order to facilitate efficient processing of the request.
Please direct all inquiries to:
Ananda L. Roy, Ph.D.
Office of Strategic Coordination (OSC)
Office of the Director (OD)