May 4, 2022
Office of The Director, National Institutes of Health (OD)
This Request for Information (RFI) seeks input on how to best collect and integrate environmental health data into the All of Us Research Program dataset.
The All of Us Research Program
The All of Us Research Program seeks to accelerate health research and medical breakthroughs to enable individualized prevention, treatment, and care for all of us. To do this, the program will partner with one million or more participants nationwide and build one of the most diverse biomedical data resources of its kind. Researchers may leverage the All of Us platform for thousands of studies on a wide range of health conditions.
Diversity is one of the core values of the All of Us Research Program. The program aims to reflect the diversity of the United States and has a special focus on engaging communities that have been underrepresented in health research in the past. Participants are from different races, ethnicities, age groups, and regions of the country. They are also diverse in gender identity, sexual orientation, socioeconomic status, educational attainment, and health status.
Importance of Environmental Data for All of Us
The precision medicine approach considers an individual’s biology, lifestyle, and environment to make more individualized preventive and medical care decisions. The collection of environmental data is critical for researchers using the All of Us resource to make discoveries that advance our understanding of how the environment influences health. The All of Us Research Program plans to use data linkages to pair participant data with data from existing national datasets that collect environmental information. In addition, All of Us is well positioned to collect environmental data from its planned cohort of at least one million diverse participants through surveys, wearable devices, and future geospatial linkages.
Currently Available Data
When responding to this Request for Information, please review and consider the data that we currently have available on our data platform, the All of Us Researcher Workbench. Data are available to researchers in several access tiers. You can refer to our data dictionary for details and use the All of Us Data Browser to explore our publicly available, aggregate data and view outcomes of interest. Within the secured, cloud-based Researcher Workbench, researchers are able to make associations through the integrated dataset by cross-referencing data from these different data types.
We are seeking information about innovative ways to collect environmental data from the All of Us cohort. Respondents may address one or more of the following topics of interest:
We encourage respondents to provide information about potential environmental research that leverages the unique structure, diversity, and disease-agnostic nature of the All of Us cohort.
Please note that you can select from the list above or add your own category. If you respond with more than one measure, please list them in priority order (most important first).
For each measure, please describe the following:
Please also consider describing the following for suggested measures:
How to Submit a Response
Responses will be accepted through May 31st, 2022. All comments must be submitted electronically on the Web Portal at: https://rfi.grants.nih.gov/?s=625848a8fa2300004a006f22
Proprietary, classified, confidential, or sensitive information should not be included in your response.
Responders are free to address any or all the questions listed above. All submitted information will be reviewed by NIH staff and contractor support personnel. Responses to this RFI are voluntary and may be submitted anonymously. You may voluntarily include your name and contact information with your response. If you choose to provide NIH with this information, NIH will not share your name and contact information outside of NIH unless required by law.
The Government will use the information submitted in response to this RFI at its discretion. The Government reserves the right to use any submitted information on public websites, in reports, in summaries of the state of the science, in any possible resultant solicitation(s), grant(s), or cooperative agreement(s), or in the development of future funding opportunity announcements.
This RFI is for informational and planning purposes only and is not a solicitation for applications or an obligation on the part of the Government to provide support for any ideas identified in response to it. Please note that the Government will not pay for the preparation of any information submitted or for use of that information.