Notice of Early Expiration of NIH Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Notices of Funding Opportunity and Guidance for Existing Recipients
Notice Number:
NOT-OD-26-006
Key Dates
Release Date:
November 17, 2025
Related Announcements
None.
Issued by
NATIONAL INSTITUTES OF HEALTH (NIH)
Purpose
Legislative authority for the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs expired on October 1, 2025.
All NIH SBIR and STTR Notices of Funding Opportunity (NOFOs) listed below are expired, effective immediately.
Active NIH SBIR and STTR awards can continue, however NIH will not issue noncompeting continuation awards for existing projects until the SBIR/STTR program is reauthorized.
| Funding Opportunity Number (FON) | Funding Opportunity Title |
| RFA-HL-26-014 | NHLBI SBIR Phase IIB Bridge Awards to Accelerate the Commercialization of Technologies for Heart, Lung, Blood, and Sleep Disorders and Diseases (R44 Clinical Trial Optional) |
| RFA-HL-26-015 | NHLBI SBIR Phase IIB Small Market Awards to Accelerate the Commercialization of Technologies for Heart, Lung, Blood, and Sleep Disorders and Diseases (R44 Clinical Trial Optional) |
| PAR-25-133 | NeuroNEXT Small Business Innovation in Clinical Trials (U44 Clinical Trial Optional) |
| PAR-24-294 | Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional) |
| PAR-24-222 | NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) for Pre-Clinical Research (R44 Clinical Trial Not Allowed) |
| PAR-24-221 | NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) for Clinical Trials and Clinical Research (R44 Clinical Trial Optional) |
| PAR-24-132 | Small Business Transition Grant for New Entrepreneurs (R43/R44 Clinical Trial Required) |
| PAR-24-131 | Small Business Transition Grant for New Entrepreneurs (R43/R44 Clinical Trial Not Allowed) |
| PAR-24-133 | Small Business Transition Grant for New Entrepreneurs (R41/R42 Clinical Trial Not Allowed) |
| PAR-24-134 | Small Business Transition Grant for New Entrepreneurs (R41/R42 Clinical Trial Required) |
| RFA-MD-24-007 | Technologies for Improving Minority Health and Eliminating Health Disparities (R41/R42- Clinical Trial Optional) |
| RFA-MD-24-006 | Innovations for Healthy Living - Improving Minority Health and Eliminating Health Disparities (R43/R44 - Clinical Trial Optional) |
| PAR-24-099 | NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44 Clinical Trial Required) |
| PAR-24-098 | Analytical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U44 Clinical Trial Optional) |
| PAR-24-096 | Clinical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U44 Clinical Trial Optional) |
| PAR-24-066 | NEI Small Business Innovation Research (SBIR) Cooperative Agreement for Early-Stage Clinical Trials with Greater than Minimal Risk (U44-Clinical Trial Required) |
| PAR-24-044 | NINDS Exploratory Clinical Trials for Small Business (R41/R42 Clinical Trial Required) |
| PAR-23-311 | NINDS Exploratory Clinical Trials for Small Business (R43/R44 Clinical Trial Required) |
| RFA-TR-23-018 | Miniaturization and Automation of Tissue Chip Systems (MATChS) (UT1/UT2 - Clinical Trial Not Allowed) |
| RFA-TR-23-017 | Miniaturization and Automation of Tissue Chip Systems (MATChS) (U43/U44 Clinical Trial Not Allowed) |
| PAR-24-063 | Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional) |
| RFA-DA-25-048 | Seeking Products to Address Social Needs impacting Substance Use Disorders (SUD) (R43/R44 Clinical Trial Optional) |
| RFA-DA-25-047 | Seeking Products to Address Social Needs impacting Substance Use Disorders (SUD) (R41/R42 Clinical Trial Optional) |
Inquiries
Please direct all inquiries to:
NIH SEED (Small business Education and Entrepreneurial Development)
Telephone: 301-827-8595
Email: [email protected]
Department of Health
and Human Services (HHS)
and Human Services (HHS)
