Notice of Intent to Publish a Funding Opportunity Announcement for Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Basic Experimental Studies with Human Required)
Notice Number:

Key Dates

Release Date:
September 06, 2023
Estimated Publication Date of Notice of Funding Opportunity :
November 24, 2023
First Estimated Application Due Date:
January 26, 2024
Earliest Estimated Award Date:
July 28, 2023
Earliest Estimated Start Date:
December 26, 2023
Related Announcements
  • November 9, 2020 - Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Basic Experimental Studies with Humans Required). See NOFO PAR-21-039.    
Issued by

Office of The Director, National Institutes of Health (OD)


The Stephen I. Katz Early Stage Investigator Research Project Grant supports an innovative project that represents a change in research direction for an early stage investigator (ESI) and for which no preliminary data exist. Applications submitted to this Notice of Funding Opportunity (NOFO) must not include preliminary data. Applications must include a separate attachment describing the change in research direction. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.

This Funding Announcement is for basic science experimental studies involving humans, referred to in NOT-OD-18-212 as “prospective basic science studies involving human participants.” These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should submit under this notice include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Studies that are NOT conducted with specific applications toward processes or products in mind and which also do not meet the clinical trial definition should submit under the appropriate ‘Clinical Trial Not Allowed’ NOFOs .This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. 

The NOFO is expected to be published in November 2023 with an expected application due date in January 2024.

Details of the planned NOFO are provided below.

Research Initiative Details

This NOFO is appropriate for ESIs who wish to initiate a research project in an area different from their previous research focus and/or training experience, and therefore have not produced preliminary data. Applications must include a separate attachment describing the change in research direction.PD/PI's who wish to proposed research projects consistent with their past work or training and/or supported by preliminary data, should apply to other NOFOs allowing for preliminary data.

Funding Information

Estimated Total Funding


Expected Number of Awards

The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. . 

Estimated Award Ceiling

Application budgets are not limited but need to reflect the actual needs of the proposed project.

Primary Assistance Listing Number(s)


Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Non-domestic (non-U.S.) Entity (Foreign Organization)
Regional Organization
Eligible Agencies of the Federal Government

Applications are not being solicited at this time. 


Please direct all inquiries to:

Randy King, Ph.D. 
National Institute of Biomedical Imaging and Bioengineering (NIBIB)