Key Dates
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NIH INCLUDE Project seeks to improve health and quality-of-life for individuals with Down syndrome. The National Institutes of Health, Office of the Director, with other NIH Institutes and Centers (ICs) (NICHD, NHLBI, NIA, NIDCD, NIMH etc.), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for a Down Syndrome Clinical Cohort Coordinating Center (DS-4C).
The DS-4C will be responsible for overall project coordination and outreach, support development of new cohorts of people with Down syndrome, and curate the metadata from the new cohorts. A companion NOFO (NOT-OD-23-134) will support the Cohort Research Sites (DS-CRS). A related NOFO (NOT-OD-23-136) will support a federated biobanking system for the INCLUDE Project.
The DS-4C will be a cooperative program committed to support the Down syndrome cohort development program. The DS-4C will provide overall management and oversight for the DS cohort development program, including coordination and communication across all subsections and cores of the program; most importantly, it will lead the effort to outreach to a broader DS community to increase Diversity, Equity, Inclusion and Accessibility (DEIA) within the DS cohort.
The DS-4C is expected to work closely with the INCLUDE data repository maintained by the INCLUDE Data Coordinating Center (DCC).
This NOFO will utilize the U54 activity code. The NOFO is expected to be published in Summer 2023 with an expected application due date in Fall 2023. Details of the planned NOFO are provided below.
The 4C’s responsibilities will cover four areas:
The total timeline for the DS-4C proposed in response to this NOFO may not exceed five years. The DS-4C will work cooperatively with Down syndrome Cohort Research Sites (DS-CRS) that will be funded through a U01 Specialized Center mechanism.
In addition, investigators proposing collaborative transdisciplinary investigations combining expertise in fields such as biochemistry, bioengineering, computational biology, molecular biology, health services, neuroscience, pharmacology, computer and data sciences, bioinformatics as well as bioethics will be encouraged to apply for this opportunity.
This NOFO will require a Plan for Enhancing Diverse Perspectives (PEDP) as part of the application.
Applicants are strongly encouraged to contact INCLUDE staff to discuss the scientific scope and feasibility of the proposal. The period of time from the estimated NOFO publication date until the estimated first application due date is designed to allow ample time for this discussion. If applying to this NOFO, the applicant is expected to work collaboratively with the respective team to jointly prepare a grant application in response to this funding opportunity that will undergo NIH peer review.
Funding Information
TBD
TBD
TBD
Applications are not being solicited at this time.
Inquiries
Please direct all inquiries to:
Sujata Bardhan, Ph.D, M.S
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Telephone: 301-435-047
Email: [email protected]
Huiqing Li, Ph.D.
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-435-0554
Email: [email protected]