January 25, 2023
PA-20-272 - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
NOT-OD-23-043 - Notice of Early Termination of NOT-OD-23-029 Notice of Special Interest (NOSI): Research on Gender Measurement (Admin Supp Clinical Trial Optional)
Office of Research on Women's Health (ORWH)
National Institute on Aging (NIA)
National Institute of Allergy and Infectious Diseases (NIAID)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
National Institute on Drug Abuse (NIDA)
National Institute on Minority Health and Health Disparities (NIMHD)
National Library of Medicine (NLM)
Sexual and Gender Minority Research Office (SGMRO)
National Cancer Institute (NCI)
Gender is a social and cultural variable that encompasses several domains, each of which influences health: gender identity and expression, gender roles and norms, gender relations, structural sexism, power, and equality and equity. Gender socialization and norms of masculinity influence boys and mens health-seeking behaviors. Structural gender inequalities limit girls and womens access to health services and contribute to health inequities. Other social variables—including race, ethnicity, socioeconomic status, and State and Federal policies—may additionally interact with gender to influence health, highlighting the importance of an intersectional approach to health research.
Disaggregation of research data on sex and gender allows identification of and responses to how sex differences and gender inequalities affect health. The two-step method of data collection – collecting sex assigned at birth and current gender identity as distinct, independent variables – is widely utilized in clinical and health care settings. In recent years, definitions and understandings of sex and gender have shifted, and few tools to measure sex and gender have been widely available and validated.
A 2022 report from the National Academies of Sciences, Engineering, and Medicine (NASEM) reviewed evidence related to measuring sex, gender, and sexual orientation. That report called for continued utilization of the two-step method of data collection. The NASEM report noted that, in the absence of other evidence, the panel recommended using the terminology female/male for current gender identity, in keeping with response options that are used by the majority of current two-step measures. However, the panel also recommended that additional research aimed at improving the quality and inclusivity of the recommended two-step gender measure be conducted by testing gender terminology for current gender identity questions (e.g., woman, man, nonbinary). Additional testing to confirm the optimal ordering of the two-step components was also recommended. As a result of publication of these recommendations on the collection of gender, the rigor of any survey that includes ‘gender ascertainment could be enhanced by incorporating a two-step approach for gender measurement and evaluating the use of gender terminology to measure gender identity.
This administrative supplement will support research testing gender terminology (e.g., woman, man, nonbinary) for measuring current gender identity as part of the two-step method of data collection (sex assigned at birth and current gender identity), within the scope of the parent grant. Supplements will support additional costs associated with incorporating, testing, validating, and/or refining a two-step method of gender ascertainment.
Supplements can only be used to meet increased costs that are within the scope of the approved award but were unforeseen when the new or renewal application or grant progress report for non-competing continuation support was submitted. None of the funds can be used to support additional items that were not included in the parent grant.
Specific Areas of Research Interest
Administrative supplements supported by this Notice of Special Interest will support research testing gender terminology (e.g., woman, man, nonbinary) for measuring current gender identity as part of the two-step method of data collection (sex assigned at birth and current gender identity).
Specific Areas of Research Interest of SGMRO
SGMRO works with the 27 NIH Institutes and Centers to advance rigorous research related to sexual and gender minority (SGM; defined for NIH research in NOT-OD-19-139) populations, including intersex individuals and those with variations in sex characteristics. For this funding opportunity, SGMRO is particularly interested in advancing research recommendations for a measurement made in the 2022 NASEM report Measuring Sex, Gender Identity, and Sexual Orientation:
The SGMRO does not have grant-making authority and can only support grants deemed meritorious after review by one of the ICs participating in this announcement and after a co-funding request is initiated through the IC. Please reach out to the relevant Scientific/Research Contact(s) identified in this announcement with any questions about IC-specific research priorities and funding. More SGM- and SGMRO-specific information is available in the NIH Strategic Plan to Advance Research on the Health and Well-being of Sexual and Gender Minorities FYs 2021-2025 and on the offices Research Resources webpage.
Specific Areas of Research Interest of NCI
Eliminating cancer-related disparities by promoting and conducting health equity research is a top priority of the National Cancer Institute. SGM populations face disparities related to cancer risk and outcomes, and they also encounter barriers in cancer prevention, treatment, and survivorship care.
NCI is interested in increasing adoption and supporting sexual orientation and gender identity (SOGI) measurement in clinical, administrative, research, and surveillance contexts, as recommended in the 2022 National Academies of Sciences, Engineering, and Medicine report, Measuring Sex, Gender Identity, and Sexual Orientation, particularly in terms of a two-step gender identity question, with a collection of both sex assigned at birth and current gender identity. NCI has an interest in research that includes an expansive collection of current gender identity options, including but not limited to, man/male, woman/female, transgender, intersex, Two-Sprit (for Indigenous populations), nonbinary, and gender-fluid.
Specific Areas of Research Interest of NIAID
NIAIDs mission is to support basic and translational research that improves the understanding, diagnosis, prevention, and treatment of infectious and immune-mediated diseases, as well as advance immunologic and transplantation strategies. Because these conditions impact the health of sexual minority and majority populations, NIAID endorses adoption of meaningful sexual orientation and gender identity (SOGI) measurement in research, clinical care, and administrative settings as recommended in the 2022 National Academies of Sciences, Engineering, and Medicine (NASEM) report, Measuring Sex, Gender Identity, and Sexual Orientation. This includes a two-step SOGI question with collection of not only sex assignment at birth but also in tandem with current gender identity. NIAID has an interest in research within its mission that will evaluate expanded gender identity options for data collection such as (but not limited to): cisgender man, cisgender woman, transgender, intersex, two-spirit (for indigenous populations), nonbinary, and gender-fluid.
Note: Specific aims added to the parent grant per SARS-CoV-2/COVID-19 Competitive Revisions process are considered as part of the parent application and are eligible to apply for a supplement under this NOSI.
PDs/PIs must also fulfill all the following requirements, otherwise their applications will be deemed non-responsive to this NOSI.
Scientific Review Process
NIH program staff will conduct administrative reviews of the application submissions; the most meritorious applications will receive funding consideration pending availability of funds.
Application and Submission Information
Elizabeth Barr, Ph.D.
Office of Research on Women's Health