Notice of Intent to Publish a Funding Opportunity Announcement for Limited Competition: Environmental influences on Child Health Outcomes (ECHO) Pregnancy and Pediatric Cohort Study Sites. Clinical Trial Not Allowed (UG3/UH3)
Notice Number:

Key Dates

Release Date:
July 06, 2022
Estimated Publication Date of Funding Opportunity Announcement:
August 01, 2022
First Estimated Application Due Date:
November 21, 2022
Earliest Estimated Award Date:
August 01, 2023
Earliest Estimated Start Date:
September 01, 2023
Related Announcements


Issued by

Office of The Director, National Institutes of Health (OD)

National Institute of Mental Health (NIMH)

National Center for Complementary and Integrative Health (NCCIH)


The Environmental influences on Child Health Outcomes (ECHO) Program Office intends to publish a funding opportunity announcement (FOA) inviting applications to renew current ECHO Cohort Study Sites to extend and expand the capacity of the ECHO Cohort to further investigate the roles of a broad range of early exposures from society to biology, including the preconception period, on ECHO’s five key child health outcome areas—pre-, peri- and postnatal, upper and lower airways, obesity, neurodevelopment, and positive health—among diverse populations.

The objectives of the intended Pregnancy and Pediatric Cohort Study Sites will be to

  1. Lead collaborative ECHO Cohort science
  2. Follow up existing ECHO Cohort participants
  3. Recruit new pregnant participants from diverse populations, their resulting offspring, and, if available, the conceiving partner
  4. Develop and implement an ECHO Cohort preconception pilot study
  5. Implement the ECHO Cohort Data and Biospecimen Collection Protocol using the ECHO Cohort consortium’s central data capture system, e.g., REDCap Central

The FOA will not support site-specific analyses and science.

This Notice is intended to allow existing ECHO UH3 Pediatric Cohort awardees or subrecipients that recruited pregnant participants during the current phase of the ECHO Cohort consortium (2016-2022) additional time to begin making arrangements to develop responsive applications.

The NIH ECHO Program Office expects to publish the FOA in August 2022.

This FOA will utilize the UG3/UH3 activity code. Details of the planned FOA are provided below.

Research Initiative Details

Additional Project Details

The NIH ECHO Program Office anticipates the FOA will encourage each applicant to submit only one Cohort Study Site application. The Program Office will define an ECHO Cohort Study Site as an institution at which participant recruitment and follow up takes place at one or multiple locations, e.g., the Cohort Study Site could be a medical system with recruitment taking place at its clinics. Applicants including more than one Cohort Study Site in their application will need to justify the multi-site structure.

The expected FOA will run in parallel with companion FOAs that solicit applications for

  • ECHO Cohort Study Sites only for a limited competition of follow-up of existing ECHO Cohort participants
  • ECHO Cohort Study Sites only for an open competition of recruitment of new pregnant participants, their resulting offspring, and, if available, the conceiving partner
  • An ECHO Coordinating Center
  • An ECHO Data Analysis Center
  • An ECHO Measurement Core
  • An ECHO Laboratory Core
Funding Information
Estimated Total Funding

Up to $117M in fiscal year 2023

Expected Number of Awards

Up to 50 awards in fiscal year 2023

Estimated Award Ceiling
Primary Assistance Listing Number(s)


Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Non-domestic (non-U.S.) Entity (Foreign Organization)
Regional Organization
Eligible Agencies of the Federal Government

Applications are not being solicited at this time. 


Please direct all inquiries to:

S. Sonia Arteaga, PHD

Environmental influences on Child Health Outcomes (ECHO) Program, Office of the Director, National Institutes of Health