• NOT-OD-20-121
• NOT-OD-20-120
• NOT-OD-20-119
• NOT-OD-21-097
• NOT-OD-21-065
• NOT-OD-21-101
• NOT-OD-21-103
• NOT-OD-20-152
• NOT-OD-20-159
• NOT-OD-21-035

• RFA-OD-20-013
• RFA-OD-21-008
• RFA-OD-21-009
• RFA-OD-20-014
• RFA-OD-20-015
• RFA-OD-20-016
• RFA-OD-20-017
• RFA-OD-20-018
• RFA-OD-20-019
• RFA-OD-20-020
• RFA-OD-20-021
• RFA-OD-20-022
• RFA-OD-20-023

Office of The Director, National Institutes of Health (OD)

The purpose of this Notice is to announce that the NIH Office of the Director intends to publish a funding opportunity announcement in the winter of 2022 to support a Rapid Acceleration of Diagnostics (RADx^®) Tribal Data Repository (RADx TDR) for American Indian and Alaska Native (AI/AN) data collected from projects supported by the RADx initiative. The RADx TDR data will allow better understanding of the impact of COVID-19, support research to better inform and develop policies to address current and future pandemics, and support and promote researchers, including AI/AN researchers The RADx TDR is intended to be an independent, tribally directed research data repository using a sovereignty-based governance structure that will provide responsible data sharing and access to researchers and their collaborators who are generating or interested in working with RADx AI/AN research data. The RADx TDR will collaborate with the RADx-Underserved Populations Coordination and Data Collection Center (RADx-UP CDCC). The TDR will not hold any biological samples.

This FOA will use the U24 Resource-Related Research Projects-Cooperative Agreement activity code and seeks to fund a single RADx TDR. The funding for this award is provided from the American Rescue Plan Act of 2021.

The RADx TDR will recognize the sovereignty of Tribal Nations by providing overarching tribally based governance, support and guidance in the following two domains: (1) Administrative Operations and Logistics and (2) Data Collection, Integration and Data Sharing. RADx funded projects are required to collect all NIH RADx Required Common Data Elements and share these data at a cadence defined by NIH and Tribal Nation data transfer and use agreements throughout the life of the project. The RADx TDR will receive RADx data directly from RADx AI/AN projects for deposit into the RADx TDR. The RADx TDR will facilitate RADx collaborative research by providing organizational and analytical infrastructure and expertise, supporting data integration and analysis, accessing AI/AN RADx research data, and coordinating across specific AI/AN populations participating in the NIH-supported RADx initiatives that are developing and validating new COVID-19 testing technologies.

This Notice encourages applications from organizations supporting investigators:

• with a documented history of working with tribal Nations and experience in Tribal sovereignty issues related to data ownership and governance, data sharing, and
• with expertise and insights into this area of data science and the establishment of independently governed data repositories .

In addition, collaborative investigations combining expertise in biostatistics, epidemiology, artificial intelligence (AI), data aggregation and harmonization, social determinants of health disparities, resilience, and tribal sovereignty, among others, will be encouraged.