Notice of Intent to Publish a Funding Opportunity Announcement for Secondary Analyses of Existing Datasets of Tobacco Use and Health (R21 Clinical Trial Not Allowed)
Notice Number:

Key Dates

Release Date:
December 23, 2020
Estimated Publication Date of Funding Opportunity Announcement:
March 08, 2021
First Estimated Application Due Date:
October 08, 2021
Earliest Estimated Award Date:
July 08, 2022
Earliest Estimated Start Date:
July 08, 2022
Related Announcements


Issued by

Division of Program Coordination, Planning and Strategic Initiatives, Office of Disease Prevention (ODP)

National Heart, Lung, and Blood Institute (NHLBI)

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

National Institute on Drug Abuse (NIDA)

National Institute of Environmental Health Sciences (NIEHS)

National Cancer Institute (NCI)


This Notice is to inform the research community that the National Institutes of Health (NIH) Tobacco Regulatory Science Program (TRSP), participating NIH Institutes and Centers (ICs), and the United States Food and Drug Administration (FDA) Center for Tobacco Products (CTP) intend to reissue the Funding Opportunity Announcement (FOA) RFA-OD-19-022 "Secondary Analyses of Existing Dataset of Tobacco Use and Health (R21 Clinical Trial Not Allowed)." When reissued, this FOA will continue to utilize the R21 grant mechanism.

This Notice is being provided to allow potential eligible applicants sufficient time to develop competitive and responsive projects.

The FOA is expected to be published in Spring 2021. Details of the planned FOA are provided below.

Research Initiative Details

The purpose of this Funding Opportunity Announcement (FOA) is to invite R21 applications proposing the innovative analysis of existing (publicly available) nationally representative U.S. cross-sectional and longitudinal data, to investigate novel scientific ideas and/or to generate new models, systems, tools, methods, or technologies that have the potential for significant impact on biomedical or biobehavioral research in areas relevant to the Food and Drug Administration (FDA) - Center for Tobacco Products (CTP). Other publicly available data sets would be considered depending on the analyses to be conducted; however, nationally representative analyses will receive priority. Applications not using nationally representative data sets will need to provide justification why the data set is unique, and why the research questions cannot be answered from a (publicly available) nationally representative data set. This FOA encourages the analyses of public use datasets that may inform tobacco regulatory actions in the United States (U.S.).

Funding Information
Estimated Total Funding

NIH, via support from the FDA Center for Tobacco products (CTP), intends to fund up to 5 R21s, corresponding to a total of up to $1 million, for fiscal year 2021. Future year amounts will depend on availability of funds.

Expected Number of Awards


Estimated Award Ceiling

The combined budget for direct costs for the entire project period may not exceed $275,000. No more than $200,000 in direct cost may be requested in any single year.

Primary CFDA Numbers


Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Non-domestic (non-U.S.) Entity (Foreign Organization)
Regional Organization
Eligible Agencies of the Federal Government

Applications are not being solicited at this time. 


Please direct all inquiries to:

Tobacco Regulatory Science Program

Office of Disease Prevention


Weekly TOC for this Announcement
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