Notice of Availability of Funds for Revision Applications for Research Centers with a Focus in Chronic Disease and the Reduction of Health Disparities (P50, P30, U54)

Notice Number: NOT-OD-19-070

Key Dates
Release Date : February 11, 2019

Related Announcements
None

Issued by
National Cancer Institute (NCI)
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institute of Neurological Disorders and Stroke (NINDS)
National Institute on Minority Health and Health Disparities (NIMHD)

Purpose

This Notice solicits competitive revision applications to support the expansion of existing P30, P50 or U54 cores and/or pilot project programs. Applicants for the competitive revisions are encouraged to form new collaborations between scientists working at different centers and scientists with expertise in varying disciplines.

Participating Institutes and Centers of the National Institutes of Health announce the opportunity for investigators with relevant active NIH-supported chronic disease research centers (P30, P50, U54) to submit competitive revision applications for funded projects that could benefit from leveraging their existing capacity to address the increasing burden of chronic diseases and to reduce health disparities. Competitive revisions must come from programs that have successfully competed for NIH funding for research in chronic high-burden diseases, exercise medicine, and health disparities. NIH encourages existing grantees to submit proposals that describe a plan where they expand their collaborative work with other centers to better understand multiple chronic high-burden diseases and the reduction of health disparities (including geographic disparities). NIH in particular encourages projects which create regional, multidisciplinary collaborations across areas in Southeasternstates with a high prevalence of multiple chronic high-burden diseases (for example, as defined by overlapping regions of the "Stroke Belt", "Obesity Belt", and "Diabetes Belt").

Competing revisions must focus on chronic high-burden diseases such as obesity, chronic cardiovascular disease, diabetes, chronic kidney disease, stroke, arthritis/autoimmune diseases, cancer, exercise intolerance and/or the reduction of health disparities in these aforementioned areas. Projects must clearly demonstrate the potential to leverage existing cohorts, networks, and/or consortia, and integrate across centers that focus on individual chronic conditions, in support of collaborative research on multiple chronic high-burden diseases and health disparities.

Examples of the types of competing revisions that are of interest include, but are not limited to the following:

  • Preventive and/or treatment interventions that:
    1. Act on upstream factors in the pathogenesis pathway such that the intervention may be reasonably anticipated to have significant downstream effects on multiple chronic high burden conditions and diseases; and/or
    2. Are reasonably anticipated to have broad efficacy by exerting a myriad of effects on multiple chronic high burden conditions and diseases
    3. Act at the individual, clinic, and/or community level(s), including natural experiments
  • Strategies to prevent and/or treat multiple chronic high-burden diseases (i.e., two or more diseases that cluster in individual patients; and that present high burden on quality of life and on public health). This could include either individual or community-level interventions (such as strategies targeting patient self-management, or social determinants of health, respectively) in the context of multiple chronic diseases.
  • Addressing health disparities in regions with a high prevalence of multiple chronic high-burden diseases.

Revision applications can support a significant expansion of the scope and research protocol approved and funded for the “parent” award on which the revision application is based. Prospective investigators can consult the contact listed below to ensure that projects will considerably contribute to achieving the goal of this Notice. Applicants may request up to 2 years of support and the parent grant must have at least two years remaining on the project. Applicant budget requests (in total costs) must not exceed 75% of the total cost of the “parent” award for the current budget period on which the revision application is based.

Applicants do not need to apply to the same FOA that the parent grant was submitted to. Instead, we will be using existing FOAs noted below for application submission. In an exception to standard practice, the participating institutes/centers (NCI, NHLBI, NIAMS, NIDDK, NINDS, and NIMHD) will accept competitive revision applications submitted to the FOAs listed below. Receipt dates indicated in the those FOAs do not apply to applications responding to this request for competitive revisions. Therefore, applicants must submit competitive revision applications by March 28, 2019 as described below.

For applicants with a current active P30:

For applicants with a current active P50:

For applicants with a current active U54 (or UL1):

For funding consideration, applicants must include “NOT-OD-19-070” (without quotation marks) in the Agency Routing Identifier field (Box 4B) of the SF424 R&R form in the Overall Component. Applications without this identifier in Box 4B will not be considered for this special initiative. In addition, applicants should include a cover letter indicating that competitive revision applications are responsive to the requirements of NOT-OD-19-70 receipt dates, and not the FOA application receipt dates.

Note that this notice announces funds for revisions that address this particular initiative on chronic diseases and health disparities only.

Applications for revisions in response to this notice must follow the aforementioned application instructions and be submitted by March 28, 2019, by 5pm at the local time of the applicant organization.

Inquiries

Please direct all inquiries to:

Gayle Lester, PhD
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Telephone: 301-594-3511
Email: lester1@mail.nih.gov

Melissa Green Parker, Ph.D.
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-827-4893 (direct)
Email: melissa.greenparker@nih.gov

David Berrigan PhD MPH
National Cancer Institute (NCI)
Telephone: 240-276-6752
Email: berrigad@mail.nih.gov

Nathan Stinson, Jr., PhD, MD, MPH
National Institute on Minority Health and Health Disparities (NIMHD)
Telephone: 301-594-8704
Email:stinsonn@mail.nih.gov

Claudia Moy, Ph.D.
National Institute of Neurological Disorders and Stroke (NINDS)
Telephone: 301-496-9135
Email: moyc@ninds.nih.gov

Mary Evans, PhD
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Telephone: 301-594-4578
Email: mary.evans@nih.gov