Notice of ORIP's Interest to Highlight Resource-Related Research Projects for Development of Animal Models and Related Materials that Address High Priority HIV/AIDS-related Research
Release Date: February 02, 2018
Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (ORIP)
ORIP is issuing this Notice to highlight its interest in receiving grant applications through PAR-16-369 focused on development of animal models or related materials that would be used to address high priority HIV/AIDS-related research as outlined in The Office of AIDS Research's (OAR) 2018 Trans-NIH Plan.
Areas of high priority include, but are not limited to, the following:
- Models that may contribute to our understanding of mechanistic aspects of HIV/AIDS pathobiology and disease progression, including infants and/or adolescents;
- Models that provide insight into latent viral reservoirs, including investigating viral persistence and eradication;
- Models that allow investigation of complications arising from coinfections and comorbidities;
- Models that develop and/or apply novel imaging technologies for HIV/AIDS prevention, treatment, or cure research.
These models may be a refinement or novel use of an existing model, such as expanded use of pigtail or cynomolgus macaque models. Development of novel models, such as the use of organoids to study host-viral interactions and early infection events, are encouraged. Any proposed model should have relevance to human HIV infection and AIDS disease progression.
Program Directors/Principal Investigators (PD/PIs) planning to submit applications on this topic are strongly encouraged to contact the scientific contacts listed in this Notice to be advised on the
appropriateness of the intended resource or research plans for this program, competitiveness of a potential application and alignment with
ORIP's program priorities.
Please direct all inquiries to:
Sheri Ann Hild, Ph.D.
Office of Research Infrastructure Programs (ORIP)
Elizabeth Stansell Church, Ph.D.
Office of AIDS Research (OAR)