Notice Number: NOT-OD-17-116

Key Dates
Release Date: September 28, 2017

Issued by
Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (ORIP)

Purpose

ORIP is issuing this Notice to highlight interest in receiving K01 grant applications from Scholars proposing nonhuman primate (NHP) studies for research areas in addition to HIV/AIDS vaccine development. High priority research topics in HIV/AIDS can be viewed at https://grants.nih.gov/grants/guide/notice-files/NOT-OD-15-137.html or Office of AIDS Research’s (OAR) 2018 Trans-NIH Plan (https://www.oar.nih.gov/strategic_plan/fy2018/OAR_18_StrategicPlan_P10_508.pdf). Preclinical NHP research is critical for new strategies in prevention and treatment, advancement of research towards sustained remission and/or eradication of virus, understanding the impact of co-morbidities, co-infections, and complications, and the basic science that underpins improved health.

Examples of NHP studies that are encouraged through this Notice include, but are not limited to:

• Simian Immunodeficiency Virus/ Simian-Human Immunodeficiency Virus (SIV/SHIV) infection prevention studies in infant, adolescent, adult, and aging NHP models
• Research for new therapeutic strategies against SIV/SHIV infection (e.g. long-acting antiretrovirals, combination therapeutic antibody studies, and new regimens for neonate/infants)
• Identification and characterization of the comprehensive latent/persistent SIV/SHIV reservoir(s) in NHPs effectively suppressed with antiretroviral therapy
• Strategies that target the latent/persistent SIV/SHIV reservoirs in the context of suppressive antiretroviral therapy
• Impact of co-morbidities and co-infections on SIV/SHIV acquisition/transmission and progression to AIDS
• Imaging and monitoring/tracking SIV/SHIV, antibodies, and immune cells.

All requirements outlined in the Funding Opportunity Announcement (https://grants.nih.gov/grants/guide/pa-files/PAR-16-347.html) need to be followed in any application (and funded award) that proposes to develop and conduct a study on one of these expanded research topics. These include the principal mentor must be an investigator actively using NHPs and the co-mentor must have extensive experience either translating NHP results to human studies or in human clinical trials.

Inquiries

Please direct all inquiries to:

Sheri Ann Hild, Ph.D.
Office of Research Infrastructure Programs (ORIP)
Telephone: 301-594-8937
Email: Sheri.Hild@nih.gov

Elizabeth Stansell Church, Ph.D.
Office of AIDS Research (OAR)
Telephone: 240-627-3201
Email: Elizabeth.Church@nih.gov