Public Comments on Proposed Guidance Regarding Significant Changes to Ongoing Animal Activities

Notice Number: NOT-OD-14-125

Key Dates
Release Date: August 26, 2014

Related Announcements

Issued by
National Institutes of Health (NIH)


This Notice provides information to Public Health Service (PHS) awardee institutions on public comments regarding proposed guidance on significant changes to ongoing animal activities.


The PHS Policy on Humane Care and Use of Laboratory Animals (Policy) requires that IACUCs review and approve, require modifications in (to secure approval) or withhold approval of proposed significant changes regarding use of animals in ongoing activities. (IV.B.7.) In NOT-OD-14-063, NIH sought input from the public on proposed guidance regarding what is considered a significant change to an ongoing animal activity that requires Institutional Animal Care and Use Committee (IACUC) review.

Public Comments

NIH received 81 comments from the public during an open comment period from March 11, 2014, to May 15, 2014,. The comments may be viewed at


For questions or further information, contact:

Office of Laboratory Animal Welfare (OLAW)
Office of Extramural Research
National Institutes of Health
Telephone: 301-496-7163