Public Comments on Implementation of the Revised International Guiding Principles for Biomedical Research Involving Animals

Notice Number: NOT-OD-14-030

Key Dates
Release Date: December 10, 2013

Related Announcements

Issued by
National Institutes of Health (NIH)


This Notice provides information to Public Health Service awardee institutions on public comments regarding the implementation of the revised International Guiding Principles for Biomedical Research Involving Animals (Guiding Principles).


NIH sought input from the public regarding any concerns they may have with the revised Guiding Principles of the Council for International Organizations of Medical Sciences (CIOMS) and the International Council for Laboratory Animal Science (ICLAS). The Public Health Service (PHS) Policy on Humane Care and Use of Laboratory Animals (Policy) requires that institutions have an approved Animal Welfare Assurance before conducting activities involving live vertebrate animals. Institutions outside the U.S. that receive PHS funding are required to have a Foreign Assurance that commits the institution to follow the Guiding Principles. PHS-Assured institutions outside the U.S. were required to implement the Guiding Principles by October 1, 2013.

Public Comments

NIH received 9 comments from the public during an open comment period from August 1, 2013 to September 30, 2013. The comments may be viewed at


For questions or further information, contact:

Office of Laboratory Animal Welfare
Office of Extramural Research
National Institutes of Health
Phone: 301-496-7163