Small Business Innovation Research (SBIR) Program Contract Solicitation Now Available

Notice Number: NOT-OD-06-091

Key Dates
Release Date: August 8, 2006
Contract Proposal Receipt Date: November 6, 2006

Issued by
National Institutes of Health (NIH) (www.nih.gov)
Centers for Disease Control and Prevention (CDC) (www.cdc.gov)

Innovative technologies and methodologies fuel progress in biomedical and behavioral research and represent an increasingly important area of the economy. The Small Business Innovation Research (SBIR) program provides support for research and development (R&D) of new or improved technologies and methodologies that have the potential to succeed as commercial products.

The purpose of this notice is to (1) announce the issuance of the Solicitation of the Public Health Service for Small Business Innovation Research Contract Proposals (PHS 2007-1) with a due date of NOVEMBER 6, 2006 for receipt of SBIR CONTRACT proposals; and (2) inform the public about the opportunities that the SBIR program offers to small business concerns as well as to scientists at research institutions.

The SBIR legislation requires the Public Health Service (PHS), Department of Health and Human Services, and certain other federal agencies to reserve 2.5 percent of their extramural research or R&D budgets for an SBIR program. The PHS SBIR set-aside requirement for FY 2006 is $572.6 million.

The offeror organization must be a small business concern as defined by the Small Business Administration and described in the Solicitation. The primary employment of the principal investigator MUST be with the small business concern at the time of award and during the conduct of the proposed project. In accord with the intent of the SBIR program to increase private sector commercialization of innovations derived from federal R&D, scientists at research institutions can play an important role in an SBIR project by serving as consultants and/or subcontractors to the small business concern. Generally, one-third of the Phase I budget may be spent on consultant and/or subcontractual costs, and, generally, one-half of the Phase II budget may be spent on such costs. In this manner, a small business concern with limited expertise and/or research facilities may benefit from teaming with a Scientist(s) at a research institution; for the scientist(s) at a research institution, this team effort provides support for R&D not otherwise obtained.

The SBIR program consists of the following three phases:

PHASE I: The objective of this phase is to determine the scientific and technical merit and feasibility and potential for commercialization of the proposed research or R&D efforts and the quality of performance of the small business concern, before consideration of further Federal support in Phase II. Generally, Phase I SBIR awards do not exceed $100,000 for direct costs, Facilities and Administrative (F&A) costs, and negotiated fee for a period generally not to exceed six months.

PHASE II: The objective of this phase is to continue the research or R&D efforts initiated in Phase I. Funding shall be based on the results of Phase I and the scientific and technical merit and commercial potential of the Phase II proposal. Only Phase I contractors are eligible to apply for Phase II funding, and Phase II proposals may be submitted upon the request of the Contracting Officer ONLY. (However, see "Fast-Track" Initiative below.) Generally, Phase II awards do not exceed $750,000 for direct costs, F&A costs, and negotiated fixed fee for a period generally not to exceed two years. That is, generally, a two-year Phase II project does not cost more than $750,000 for that project. Only one Phase II award may be made for any SBIR project.

PHASE III:
The objective of this phase is for the small business concern to pursue, with non-SBIR funds, the commercialization of the results of the research or R&D funded in Phases I and II.

"FAST-TRACK" INITIATIVE:
(Applicable only to proposals submitted to the National Institutes of Health [NIH] and only if an awarding component indicates it is accepting Fast Track proposals for a particular topic.)

The Fast-Track initiative is an opportunity for small business concerns to submit both a Phase I and Phase II proposal for concurrent peer review. This initiative also has the potential to minimize any funding gap between Phase I and Phase II. Proposals must be prepared in accordance with Phase I and Phase II proposal preparation instructions.

Following are the research topics contained in the Solicitation of the Public Health Service for Small Business Innovation Research Contract Proposals (PHS 2007-1) for the contract proposal RECEIPT DATE of NOVEMBER 6, 2006:

National Institutes of Health

National Cancer Institute (NCI)

  • 229 Development of Molecular Pharmacodynamic Assays for Targeted Therapies
  • 230 Synthesis of Stable Isotope-Labeled Steroids as Internal Standards for the Measurement of Endogenous Steroid Hormones in Biologic Samples by Liquid Chromatography Mass Spectrometry (LC-MS)
  • 231 Quantitative Assay for O6-Carboxymethyl Guanine DNA Adducts
  • 232 Development of Anti-Cancer Agents
  • 233 Development of Software Systems to Facilitate the Use of Electronic Data Records in the Collection of Population-Based Cancer Surveillance Data
  • 234 Develop Automated Methods to Identify Environmental Exposure Patterns in Satellite Imagery Data
  • 235 Home Centered Coordinated Cancer Care System
  • 236 Antibody Array for Cancer
  • 237 Glycan Arrays for Biomarker Discovery and Validation 238 Development of Clinical Automated Multiplex Affinity Capture Technology for Detecting Low Abundance Cancer-related Proteins/Peptides
  • 239 Development of Alternative Affinity Capture Reagents for Cancer Proteomics Research
  • 240 Early Diagnostics Using Nanotechnology-Based Imaging and Sensing
  • 241 Multifunctional Therapeutics Based on Nanotechnology

National Heart, Lung, and Blood Institute (NHLBI)

  • 035 Ultrasonic Wave Transmitter, Transmission Line and Receiver for Interventional MRI
  • 036 Ultrafine Magnesium Biodegradable Stents for Orphan Disease Applications
  • 037 Critical Technologies for Ventricular Assist Devices
  • 038 Production of Generic Modified Hemoglobin

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

  • 029 Development of Correlational Alcohol-Relevant Database from Mouse or Rat Transcriptome and Proteome

National Institute of Child Health and Human Development (NICHD)

  • 022 Development of a User-based Information System for Mobility Needs
  • 082 Development of Novel Drug Delivery Systems for Treatment Medications
  • 085 Metabolomics in Drug Abuse Research
  • 086 Marketing Evidence-Based Prevention Interventions for Substance Abuse and Related HIV Prevention
  • 087 Development of State-of-the-Art Mechanisms for Epidemiological Research
  • 088 Automation of the Development of Electronic Data Capture (EDC) System for Clinical Trials Data Collection and Management
  • 089 Development of Practical Training Materials for Evidence-Based Treatment
  • 090 Develop a Real-Time fMRI Feedback System that Allows Drug Abusers to Control their Cravings and Urges and/or Increase their Self-Control of their Drug Taking
  • 091 Design and Synthesis of Treatment Agents for Drug Abuse
  • 092 Mechanisms and Methods to Maximize Data Utilization

National Institute of Environmental Health Sciences (NIEHS)

  • 101 Gene Expression and Molecular Imaging to Identify Early Biomarkers and Staging of Lung Cancer Following Environmental Exposures
  • 102 Quantitative Analysis of Protein Expression in Paraffin Embedded Rodent Tissues
  • 103 Development of an ELISA for Measuring Serum Levels of NAG-1/MIC/GDF15
  • 104 Identifying Biomarkers to Predict Renal Disease in Rodent Cancer Bioassays

National Institute of Mental Health (NIMH)

  • 057 Development of Iterative Continuous Clinical Improvement (ICCI) Models for Mental Disorders Utilizing Clinical Trials and other Relevant Research Sources
  • 058 Families as Research and Treatment Partners: Developing Evidence Based Decision Aids for Mental Health Treatment Decisions

Centers for Disease Control and Prevention (CDC)

Immunization Safety Office (ISO)

  • 001 Develop Methods to Enhance Administration of Vaccines, Including Live Virus Vaccines, Through the Respiratory Track
  • 002 Disposable-Cartridge Jet Injector Technology

National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP)

  • 025 Development and Evaluation of Eyewear for Citrus Workers
  • 026 Linking GIS Technology with Essential Public Health Service
  • 027 Tools to Enhance the Utilization of Tobacco Cessation Quitlines

National Center for HIV, STD and TB Prevention (NCHSTP)

  • 019 Development of Novel Genotyping Procedures for Mycobacterium Tuberculosis
  • 020 New Laboratory Tests for Tuberculosis and Detection of Drug Resistance
  • 021 Development of a Novel Information System for Remote TB Control and Prevention Programs

National Center on Birth Defects and Developmental Disabilities (NCBDDD)

  • 006 Generic Targeting of Thrombotic Risk

Inquiries

Eligibility requirements, definitions, submission procedures, review considerations, contract proposal forms and instructions, and other pertinent information, including the "Fast-Track" Initiative, are contained in the Solicitation of the Public Health Service for Small Business Innovation Research Contract Proposals (PHS 2007-1) for the proposal receipt date of November 6, 2006. The PHS SBIR Contract Solicitation PHS 2007-1, including proposal forms, is available electronically through the National Institutes of Health's "Small Business Funding Opportunities" home page at http://grants.nih.gov/grants/funding/sbir.htm. Be sure to use the appropriate CONTRACT PROPOSAL forms as they differ from the SF424 (R&R) GRANT application forms.

Note: The SBIR Phase I Contract Solicitation will only be available via electronic means. Potential offerors are encouraged to check the NIH Small Business Funding Opportunities Web site for updates on the program. Any updates or corrections to the solicitation will be posted there.

Contracting Officers

Any small business concern that intends to submit an SBIR contract proposal under this Solicitation should provide the appropriate contracting officer(s) with early, written notice of its intent, giving its name, address, telephone, and topic number(s). If a topic is modified or canceled before this Solicitation closes, only those companies that have expressed such intent will be notified.

National Institutes of Health (NIH)

National Cancer Institute (NCI)
Ms. Mary Landi-O Leary
Phone: (301) 435-3807
Fax: (301) 480-0309
Email: ml186r@nih.gov

National Heart, Lung, and Blood Institute (NHLBI)
Mr. John Taylor
Phone: (301) 435-0327
Fax: (301) 480-3338
E-mail: taylorjc@nhlbi.nih.gov

National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Mr. Patrick Sullivan
Phone: (301) 594-7728
Fax: (301) 443-3891
Email: sullivanp@mail.nih.gov

National Institute of Child Health and Human Development (NICHD)
Mr. Robert Stallings
Phone: 301-496-6965
Fax: 301-402-3676
Email: stallinb@mail.nih.gov

National Institute on Drug Abuse (NIDA)
Mr. Craig Sager
Phone: (301) 443-6677
Fax: (301) 443-7595
Email: cs591t@nih.gov

National Institute of Environmental Health Sciences (NIEHS)
Ms. Jo Ann Lewis
Phone: (919) 541-7894
Fax: (919) 541-2712
Email: Lewis9@niehs.nih.gov

National Institute of Mental Health (NIMH)
Ms. Suzanne Stinson
Phone: (301) 443-2696
Fax: (301) 443-0501
Email: sstinson@mail.nih.gov

Centers For Disease Control and Prevention

Immunization Safety Office (ISO)

Mr. Jeff Miller
Phone: 770-488-2651
Fax: 770-488-2777
Email: afx2@cdc.gov

National Center for HIV, STD, and TB Prevention (NCHSTP)

Ms. Raquel Powell
Phone: 404-639-6401
Fax: 404-639-8095
Email: RPowell2@cdc.gov

National Center on Birth Defects and Developmental Disabilities (NCBDDD) and National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP)

Mr. Carlos M. Smiley
Phone: 770/488-2754
Fax: 770/488-2777
Email: CSmiley1@cdc.gov

Those interested in the PHS small business research grant programs may access electronically (http://grants.nih.gov/grants/funding/sbir.htm) the Omnibus Solicitation of the Public Health Service for Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Grant Applications (PHS 2006-2). There is one grant application receipt date (December 1, 2006) remaining for calendar year 2006.

To better understand the differences between grants and contracts, see http://grants.nih.gov/grants/funding/contracts_vs_grants.htm.