Notice Number: NOT-OD-06-020

Key Dates
Release Date: December 12, 2005

Issued by
National Institutes of Health (NIH), (http://www.nih.gov/)

The National Institutes of Health has contracted with Deltagen Inc. of San Carlos , Calif. , and Lexicon Genetics Incorporated of The Woodlands, Texas , to provide NIH and its scientific partners with access to about 251lines of knockout mice that have been extensively characterized. Notice about the availability of these animals was issued November 15, 2005: https://grants.nih.gov/grants/guide/notice-files/NOT-OD-06-012.html. At that time, the NIH had not yet received the data detailing the impact of the specific gene deletion on the mouse's phenotype, which includes appearance, health, fitness, behavior, ability to reproduce, and radiological and microscopic data. These data are now available and can be found at: http://www.nih.gov/science/models/mouse/deltagenlexicon/list.html and http://www.informatics.jax.org/external/ko.

For more information on what knockout mice are, how they are made, what they are used for, and information on how to obtain knockout mice and phenotypic data go to http://www.nih.gov/science/models/mouse/deltagenlexicon/index.html.

Inquiries

For questions or further information, contact:

Christopher P. Austin, M.D.
austinc@mail.nih.gov

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