Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Grant Programs – Addendum to NOT-OD-05-027

Notice Number: NOT-OD-05-031

Key Dates
Release Date: February 3, 2005

Issued by
National Institutes of Health (NIH), (

Addendum to NOT-OD-05-027

The purpose of this notice is to add twelve new SBIR topics to the 2005 NIH SBIR/STTR Omnibus Solicitation for the Division of Oral Health, National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP) at the CENTERS for DISEASE CONTROL AND PREVENTION (CDC). These topics are in addition to those published in the SOLICITATION of THE NATIONAL INSTITUTES OF HEALTH (NIH), CENTERS for DISEASE CONTROL AND PREVENTION (CDC), and FOOD AND DRUG ADMINISTRATION FDA) for SMALL BUSINESS INNOVATION RESEARCH (SBIR) and SMALL BUSINESS TECHNOLOGY TRANSFER STTR) GRANT APPLICATIONS (PHS 2005-2)

Division of Oral Health

The Division of Oral Health seeks to improve the oral health of the nation by extending the use of proven strategies to prevent oral diseases, enhancing surveillance of oral diseases, strengthening the nation's oral health infrastructure, and guiding infection control in dentistry. At the core of the DOH mission is the critical relationship between oral health and general health and well-being. Division programs focus on educating the public, public health and clinical professionals, and policy makers on steps that individuals and communities can take to improve oral health at different ages throughout the lifespan, and serving as a resource for these efforts.

A. Providing Safe Dental Care

Infection control in the dental care environment remains essential to ensuring the public's safety and retaining its confidence. In the 15 years since CDC published its first guidelines for infection control in dentistry, infection control practices have dramatically improved. Nevertheless, the potential for disease transmission during visits to the dentist continues to arouse intense public interest and media scrutiny. To minimize this potential, CDC assesses the risks of infectious disease transmission, updates guidelines to minimize those risks, investigates disease outbreaks and environmental hazards in dental settings, and identifies emerging problems. Infection control activities address the “Healthy People 2010" priority areas in Occupational Safety and Health, Immunization and Infectious Diseases, and HIV Infection.

1. Develop surveillance system(s) and outcome measures for adverse events related to exposure to pathogens and other hazardous agents during dental treatment.
2. Develop methods or models for evaluating the effectiveness and cost-effectiveness of infection control interventions.
3. Develop dental devices with passive safety features that meet or exceed performance criteria identified by CDC (
4. Develop devices, both accurate and passive, to measure biofilm or bacterial contamination in dental waterlines.
5. Develop educational/training materials and demonstrate their effectiveness in on-the-job training of dental assistants in dental office infection control and quality assurance.
6. Develop training and educational materials for using the oral rapid HIV screening test in dental facilities to identify cases of HIV infection that may otherwise go undetected.

B. Oral Health

In collaboration with several partners, the Division develops national plans and supports programs in specific areas of oral health including appropriate use of fluorides and sealants to prevent dental caries (tooth decay); activities that address the oral health needs of an aging population; and implementation of strategies to reduce disparities in oral health status. This includes expanding the capacity and ability of state health departments to implement community water fluoridation and school-based/-linked dental sealant programs. The following are topics of interest in oral health.

1. Develop accurate, non-invasive methods or devices to aid in diagnosis, measurement, and recording of dental caries.
2. Identify biomarkers or develop methods or devices to measure total fluoride exposure.
3. Develop oral hygiene products or devices for adults with motor difficulties.
4. Develop innovative fluoride delivery systems for home use among persons at increased risk for dental caries (tooth decay).
5. Develop innovative methods to defluoridate water with high natural fluoride concentrations.
6. Develop innovative sealant materials, supplies or equipment for use by sealant programs in non-traditional dental settings.


For technical information, contact:

Jennifer L. Cleveland, D.D.S., M.P.H.
Dental Officer/Epidemiologist
Division of Oral Health
Mailstop F-10
Atlanta, GA 30341
Phone: (770) 488-6066
FAX: (770) 488-6080

For administrative and business management information, contact:

Mr. Curtis Bryant
Centers for Disease Control and Prevention
Procurement and Grants Office
Mail Stop E14
2920 Brandywine Road
Atlanta, Georgia 30341
Phone: (770) 488-2806
Fax: (770) 488-2828

For grants specific information, contact:

Ms. Sharron Orum
Centers for Disease Control and Prevention
Procurement and Grants Office
Mail Stop K70
2920 Brandywine Road
Atlanta, Georgia 30341
Phone: (770) 488-2716
Fax: (770) 488-2777

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