Release Date:  December 15, 1999

NOTICE:  OD-00-005

National Institutes of Health

The National Institutes of Health (NIH) is implementing a trans-institute 
initiative to improve adherence to therapeutic regimens. The Office of 
Behavioral and Social Sciences Research, Office of the Director, NIH (OBSSR), 
and several NIH Institutes are developing a Request for Applications (RFA) to 
encourage behavioral and social research on the effectiveness of 
interventions to improve adherence to therapeutic regimens involving 
pharmacological treatments in various settings. The forthcoming RFA will 
solicit regular research (R01) grant applications where (1) the therapeutic 
regimen is for an existing illness or condition as opposed to a primary 
disease prevention or health promotion regimen and (2) the adherence 
intervention has been demonstrated to be effective in either (a) controlled 
settings (e.g., laboratories, clinical trials), (b) has been tested only with 
limited populations (e.g., small samples or samples from restricted 
populations) or with short periods of follow-up, or (c) has been researched 
on a health condition or treatment regimen different from that in the 
proposed research. In addition, the RFA will encourage research on how to 
adjust interventions to take into account the characteristics of different 
patient groups as well as patients suffering from and receiving treatments 
for multiple acute and/or chronic illnesses and conditions. The RFA will be 
an opportunity to conduct research cutting across the traditional boundaries 
of responsibility of the participating NIH Institutes and Centers (ICs).
The planned release date for the RFA is in late January 2000, with 
applications being due in April 2000. OBSSR/NIH anticipates making available 
$3 million for approximately six awards in September 2000.The announcement 
will be published in the NIH Guide to Grants and Contracts in the usual 
manner. You may also be informed of the publication of the RFA and receive 
subsequent information by subscribing to the OBSSR’s automated e-mail 
service. To subscribe, please send a message addressed to 
listserv@list.nih.gov. Leave the subject line blank. The message body should 
read SUBscribe RFA-ADHERENCE-L [your full name]. The message is case 
sensitive; so capitalize as indicated! Don't include the brackets. For 
example, for Robin Smith to subscribe, the message would read “SUBscribe RFA-
ADHERENCE-L Robin Smith” (omit the quotation marks). You will receive a 
confirmation of your subscription along with instructions on how to use the 
LISTSERV and how to unsubscribe.


Please direct general inquiries in regard to this notice to:

Ronald P. Abeles, Ph.D.
Office of Behavioral and Social Sciences Research
Office of the Director
National Institutes of Health
Gateway Bldg., Rm. 2C234, MSC 9205
7201 Wisconsin Avenue
Bethesda, MD 20892-9205
Telephone: 301-496-7859
Fax: 301-435-8779
E-mail: Abeles@nih.gov

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