Notice of Intent to Publish a Funding Opportunity Announcement for Impact of the Microbiome Gut-Brain Axis on ADRD (R01 Clinical Trial Not Allowed)
Notice Number:

Key Dates

Release Date:
March 24, 2022
Estimated Publication Date of Funding Opportunity Announcement:
July 05, 2022
First Estimated Application Due Date:
September 06, 2022
Earliest Estimated Award Date:
June 01, 2023
Earliest Estimated Start Date:
July 01, 2023
Related Announcements


Issued by

National Institute of Neurological Disorders and Stroke (NINDS)


The National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute on Aging (NIA) intend to publish a Funding Opportunity Announcement (FOA) to solicit applications for basic and translational research on the impact of the microbiome gut-brain axis on Alzheimer’s Disease Related Dementias (ADRD). While there is growing evidence that the microbiome is an important factor that contributes to overall health and a variety of diseases and disorders, the role of intestinal microbiota dysfunction in specific ADRDs has not been adequately addressed. Furthermore, there is a need for more engagement of the ADRD research community to better understand the mechanistic relationship between the gut-brain axis and dementia-related diseases. This FOA will support mechanistic and early translational research focused on a more rigorous in-depth examination of the potential interactions between the gut microbiome and genetic and non-genetic molecular targets that influence ADRD. It is expected that these studies will address the clinical relevance of the gut microbiome on disease initiation, progression, or modification that will lead ultimately to better therapeutic interventions.

This Notice is being provided to allow potential applicants sufficient time to develop integrated multidisciplinary collaborations and responsive projects.

The FOA is expected to be published in Summer 2022 with an expected application due date in Fall 2022.

This FOA will utilize the R01 (Clinical Trials Not Allowed) activity code.

Research Initiative Details

The proposed FOA will solicit team science between ADRD researchers that have deep expertise in basic, translational, and clinical research, and scientists with expertise in intestinal and mucosal physiology, immunology, and metabolomics within the gut microbiome, and the potential use of pre- and probiotics as an intervention. The FOA will support research on ADRDs including Frontotemporal Degeneration, Lewy Body Dementia, Vascular Contributions to cognitive Impairment and Dementia, and Mixed Etiology Dementias. The scope of the FOA will include mechanistic, translational, and human subjects (clinical trials not allowed) research. Several examples of projects include, but are not limited to, mechanistic research on the relationship between microbiota within human samples and ADRD, in vitro and in vivo animal models of ADRD that incorporate modification of the gut microbiome, and pre-clinical testing of probiotics and other interventions. Outcomes include a better understanding of the potential influence of the gut microbiome on ADRDs and more engagement of the ADRD research community within this field of study.

Funding Information
Estimated Total Funding


Expected Number of Awards


Estimated Award Ceiling


Primary Assistance Listing Number(s)


Anticipated Eligible Organizations
Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
Indian/Native American Tribal Government (Federally Recognized)
Non-domestic (non-U.S.) Entity (Foreign Organization)
Eligible Agencies of the Federal Government

Applications are not being solicited at this time. 


Please direct all inquiries to:

David A. Jett, Ph.D.