July 29, 2021
PA-20-272 – Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
Personal history of traumatic brain injury (TBI) is recognized as an environmental risk factor for all-cause dementia, Alzheimer’s Disease (AD) and Alzheimer’s Disease Related Dementias (ADRD) Risk from prior exposure to TBI likely derives distinct pathological processes related both to “dosing” of brain injury (a combination of both frequency and severity of exposure to head impacts and/or explosive blast) and patient-specific vulnerabilities. To better understand these factors and the prevalence of prior TBI exposure in AD/ADRD populations it is critical to collect validated instruments for assessing lifetime history of TBI exposure in existing cohorts diagnosed with AD/ADRD-relevant dementia.
In 2011, the National Alzheimer's Project Act (NAPA) allocated resources "to prevent and effectively treat Alzheimer's by 2025." Since then, the National Institute on Aging (NIA) and the National Institute of Neurological Disorders and Stroke (NINDS) have held multiple research summits to assess the needs and opportunities relevant to this goal for Alzheimer's Disease (AD) and Alzheimer's Disease Related Dementias (ADRD). By supplementing AD/ADRD awards to collect patient experience with TBI-related events, this Notice addresses the AD/ADRD milestone 1.N “Encourage crosstalk and interdisciplinary collaboration between TBI and dementia researchers” specifically the established success criteria to “Support the addition of AD/ADRD assessments to existing TBI cohort studies.”
These administrative supplements will provide funding to existing NINDS-funded AD/ADRD relevant cohort studies to support the inclusion/addition of NINDS Common Data Elements (CDEs) for life-time exposure to TBI (Ohio State University TBI Identification Form), other FITBIR CDE for life-time TBI exposure measures (e.g. FITBIR Injury History Form) or Brain Injury Screening Questionnaire (BISQ), and other relevant TBI-related NINDS CDEs to current clinical assessment batteries. Data will be available to better understand the prevalence of TBI history in these populations and could be hypothesis generating for studying the pathophysiology underlying TBI as a risk factor for AD/ADRDs.
It is expected that data collected from this administrative supplement program will follow Findable, Accessible, Interoperable, and Accessible (FAIR) data practices as outlined in the NIH Data Science Strategic plan.
The proposed studies must be within the scope of the peer-reviewed activities specified within the parent award. Active awards with project end dates in FY 2023 or later are eligible. The award may not be in a terminal no-cost extension or going into a no-cost extension in FY 2022.
Only supplement applications to parent awards that have an NS designation for NIH institute are eligible to apply to the NINDS for support under this NOSI.
Description of circumstances for which administrative supplements are available.
Application and Submission Information
Applications for this initiative must be submitted using the following opportunity or its subsequent reissued equivalent.
Nsini Umoh, Ph.D.
National Institute of Neurological Disorders and Stroke (NINDS)