March 16, 2021
PA-20-272 - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
National Institute of Neurological Disorders and Stroke (NINDS)
Sleep disturbances/circadian disruption is a key clinical issue in dementia patients. Between 40 and 70% of older adults suffer from sleep disturbances or disorders, which are especially prevalent among patients with Alzheimer's Disease and Alzheimer’s Disease Related Dementias (AD/ADRD), i.e., Frontotemporal degeneration (FTD), Lewy Body Disease (LBD), Vascular contributions to Cognitive Impairment and Dementia (VCID), and Mixed Etiology Dementias (MED). The Alzheimer's Disease Research Summits specifically recommended to “invest in understanding the integrative physiology of sleep and elucidating the short- and long-term consequences of disrupted and optimized sleep on brain aging and AD.” Moreover, NIA’s AD/ADRD Research Implementation Milestone 2.F plans to "create new research programs aimed at understanding the integrative physiology of circadian rhythms and sleep and its impact on brain aging and the risk of AD and AD-related dementias at multiple levels (epigenetic, gene expression, proteomic, neuronal, network, systems) to identify new targets and approaches for AD prevention."
The purpose of this one-year administrative supplement program is to facilitate collaborative research to better understand the bi-directional relationship between chronic sleep disturbances/circadian disruption and AD/ADRD pathogenesis. This notice encourages eligible members of the AD/ADRD research community with AD/ADRD awards to apply for supplemental funds to establish new collaborations with sleep/circadian researchers for the advancement of research on the association between sleep disturbances/circadian disruptions with ADRD. This initiative aims to investigate the potential of sleep/circadian-related treatment as a modifier of the development and progression of neurodegeneration.
The proposed studies must be within the scope of the peer-reviewed activities specified within the parent award and collaborators may not have a prior history of collaboration. Active awards with project end dates in FY 2022 or later are eligible. The award may not be in a terminal no-cost extension or going into a no-cost extension in FY 2021.
Only supplement applications to parent awards that have an NS designation for NIH institute are eligible to apply to the NINDS for support under this NOSI.
.
Application and Submission Information
Applications for this initiative must be submitted using the following opportunity or its subsequent reissued equivalent.
All instructions in the SF424 (R&R) Application Guide and PA-20-272 must be followed, with the following additions:
Dr. Janet He
National Institute of Neurological Disorders and Stroke (NINDS)
Telephone: 301-496-9964
Email: yh74k@nih.gov