Notice Number: NOT-NS-17-019
Release Date: March 20, 2017
Estimated Publication Date of Announcement: May 2017
First Estimated Application Due Date: September 2017
Earliest Estimated Award Date: July 2018
Earliest Estimated Start Date: September 2018
National Neurological Disorders and Stroke (NINDS)
The National Institute of Neurological Disorders and Stroke (NINDS), intends to issue a Funding Announcement (FOA) to solicit applications for NINDS StrokeNet Regional Coordinating Centers (U24) to participate as StrokeNet clinical recruitment centers during the next 5 years of the program. The goal of this existing network (www.nihstrokenet.org) is to maximize efficiencies to develop, promote and conduct high-quality, multi-site clinical trials focused on key interventions in stroke prevention, treatment, and recovery with the objective to have a balanced portfolio between all three approaches. Exploratory phase 1/2 and confirmatory phase 3 clinical trials as well as biomarker-validation studies that are immediately preparatory to trials will be coordinated through separate National Clinical Coordinating and Data Management Centers. Efficiency is fostered through the use of master trial agreements and a central IRB. Leaders drawn from both the clinical and basic stroke science communities at the sites will contribute to the development of network clinical trial proposals for peer review, as well as planning for execution of proposals coming from outside of the network, including trials that result from a Collaborative Research and Development Agreement (CRADA) between the NINDS and an Industry partner. The Network will also be uniquely poised to rapidly collaborate with other existing networks or International Consortia to conduct larger, definitive trials of promising interventions for the treatment of stroke.
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and competitive research programs.
The FOA is expected to be published in Summer 2017 with an expected receipt date in October 2017.
This FOA will utilize the U24 activity code. Details of the planned FOA are provided below.
The NINDS Stroke Trials Network will utilize Cooperative Agreements (U24) to support clinical recruiting sites in the Stroke Trials Network for up to 5 years. Each funded site in the network will have access to stroke patients and have demonstrated their ability to enroll patients into stroke trials. Each site will also have strong collaborative relationships between Vascular Neurology, Emergency Medicine, Interventional Neuroradiology, Neurosurgery, NeuroIntensive care, Neuroimaging, Stroke Rehabilitation, and Pediatric Neurology in order to ensure a commitment to offer every eligible patient the opportunity to participate in a trial conducted through the Network. In addition, network sites will include a stroke research training program. All network sites will be committed to increase the value of clinical research data through an aggressive data sharing plan.
APPLICATIONS ARE NOT BEING SOLICITED AT THIS TIME.
Please direct all inquiries to:
Scott Janis, Ph.D.
National Institute of Neurological Disorders and Stroke (NINDS)
Telephone: (301) 496-9135