Request for Information (RFI): Updating the Alzheimer's Disease-Related Dementias Research Priorities

Notice Number: NOT-NS-15-045

Key Dates
Release Date: November 4, 2015
Response Date: December 18, 2015

Related Announcements

Issued by
National Institute of Neurological Disorders and Stroke (NINDS)
National Institute on Aging (NIA)
Office of Disease Prevention (ODP)


The National Alzheimer’s Project Act, which became law in January 2011, directed the Health and Human Services Secretary to establish a National Plan to overcome Alzheimer’s disease and related dementias. First released in 2012 and updated annually, the National Plan to Address Alzheimer’s Disease includes goals for the research, clinical care and long-term services and support that are needed to meet the challenge of addressing Alzheimer s. Goal 1 of the National Plan is to prevent and effectively treat Alzheimer’s disease and related dementias by 2025. To meet this goal, NIH has convened a series of summits to develop research recommendations for advancing research on Alzheimer's disease and related dementias. The Alzheimer’s Disease-Related Dementias: Research Challenges and Opportunities (ADRD 2013) Summit held on May 1-2, 2013 established prioritized recommendations for research on frontotemporal degeneration, health disparities, Lewy body dementia, multiple etiology dementias, and vascular contributions to dementia. ADRD 2013 research recommendations and milestones are included in the National Plan and were used to develop the ADRD research budget that is included as part of the Alzheimer’s disease bypass budget proposal for fiscal year 2017.

On March 29-30, 2016, the National Institute of Neurological Disorders and Stroke (NINDS), in collaboration with the National Institute on Aging (NIA) will convene the Alzheimer's Disease-Related Dementias Summit 2016 (ADRD 2016) to assess progress and revise and update the recommendations from ADRD 2013. These updated recommendations will be included as part of the National Plan and used to guide future bypass budget proposals and NIH investments in ADRD research.

The purpose of this time-sensitive Request for Information (RFI) is to seek input from scientists, clinician, patients, advocates, and the broader community on the most important needs and promising opportunities for research on ADRDs. This information will be used by committees of scientists, clinicians, and other members of the public to revise and update the ADRD 2013 research recommendations. Revised recommendations will presented to the public for further comment at the ADRD 2016, which will take place on March 29-30, 2016 at the Natcher Conference Center on the main NIH campus in Bethesda, MD. (Register to attend ADRD 2016 at Registration is free and open to the public.) Recommendations developed through this Summit will guide research on ADRDs over the next 10 years as we strive to achieve the goal of preventing or effectively treating Alzheimer’s disease and related dementias by 2025.

Information Requested

The NINDS and NIA invite scientists, clinicians, caregivers, advocates, patients, and the general public to provide comments and suggestions regarding the ADRD 2013 research recommendations (ADRD 2013 research recommendations and more information about ADRD 2013 can be found at ). These comments may include but are not limited to priority level of the recommendation relative to other recommendations; suggestions for revisions, updates or clarifications of ADRD 2013 recommendations; and suggestions for new recommendations that were not included in ADRD 2013. The collected comments will be reviewed and considered during the development of draft recommendations that will be presented for further comment at ADRD 2016 on March 29-30, 2016 at the Natcher Conference Center on the main NIH campus.

How to Submit a Response

Responses to this RFI must be submitted electronically using the web-based format at: Responses will be accepted until December 18, 2015. Responses to this RFI are voluntary. Submitted information will not be considered confidential.

This request is for information and planning purposes only and should not be construed as a solicitation or as an obligation on the part of the Federal Government. The NIH does not intend to make any awards based on responses to this RFI or to otherwise pay for the preparation of any information submitted or for the Government's use of such information.

The NIH will use the information submitted in response to this RFI at its discretion and will not provide comments to any responder’s submission. However, responses to the RFI may be reflected in future funding opportunity announcements. The information provided will be analyzed and may appear in reports. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).


Please direct all inquiries to:

Christine Torborg, Ph.D.
Office of Science Policy and Planning
National Institute of Neurological Disorders and Stroke (NINDS)