Notice Number: NOT-NS-10-012

Key Dates
Release Date:  March 3, 2010

Issued by
National Institute of Neurological Disorders and Stroke (NINDS) (http://www.ninds.nih.gov)

Background

The NIH Molecular Libraries and Imaging Roadmap Initiative (http://nihroadmap.nih.gov/molecularlibraries/index.asp) is a major NIH effort to broaden access to rapid assay technologies.  The overall goal of the Initiative is to facilitate the creation of a public database of biological information about small molecule chemical structures, which then seeds the further development of small molecule pharmacological tools for biological research.  The Assay Development for HTS Program is one component of this Initiative, and funds the development and adaptation of biological assays for use in automated high throughput molecular screening (HTS).  It is intended that this Program promote the development of automated screening projects that can be submitted to the Molecular Libraries Probe Production Centers Network (MLPCN: www.mli.nih.gov), which employs a library of chemical compounds that are part of the Molecular Libraries Small Molecule Repository. 

Purpose

For 2010, administrative supplements will be provided to NINDS-relevant projects funded in the Roadmap Molecular Libraries Assay Development for HTS Program.  Investigators successfully submitting new, HTS-ready projects from this Program to the MLPCN, via the “Fast Track direct entry” process described in the RM-08-024 announcement (http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-08-024.html), can request a supplement of up to $50,000 (total cost) from NINDS. 

Submitting an Administrative Supplement Request

The Investigator is required to clarify in a letter how the funds will be used to support a collaboration with the assigned MLSCN Center.  It is expected that the funds will enable the Investigator to participate in probe development activities that are related to their project.  These activities may include, but are not limited to, direct secondary screening support, and the provision of specialty reagents required for the HTS.  These activities can complement, but not directly overlap, those proposed and funded from other sources. Qualifying Investigators must have an active grant award, and are encouraged to file a no-cost extension of this award as needed to permit administrative supplementation during the HTS collaboration. 

IMPORTANT:  The research proposed by the NIH grantee in the supplement application must be within the original scope of the NIH-supported grant project.  The funding mechanism being used to support this program, administrative supplements, can be used to cover cost increases that are associated with achieving certain new research objectives as long as they are within the original scope of the project.  Any cost increases need to result from making modifications to the project in order to take advantage of opportunities that would increase the value of the project consistent with its originally approved objectives and purposes.
Requests will be accepted until the end of August, 2010, and will be reviewed on a monthly basis.

Inquiries

For further information, contact:

Mark Scheideler, Ph.D.
Senior Scientific Officer
Program Director, Molecular Libraries Assay Diversity
Office of Translational Research, NINDS
National Institutes of Health
6001 Executive Blvd., Room  2107
Bethesda, Maryland 20892-9527, U.S.A. 
Phone: 301-496.1779
Fax: 301-402.1501
Email: scheidelerm@ninds.nih.gov