COLLABORATIVE RESEARCH IN COMPUTATIONAL NEUROSCIENCE (CRCNS)   
INNOVATIVE APPROACHES TO SCIENCE AND ENGINEERING RESEARCH ON BRAIN 
FUNCTION: NSF 04-514 (REPLACES NSF 02-018)

RELEASE DATE:  November 6, 2003

NOTICE:  NOT-NS-04-003 (See Replacement Notice NOT-NS-08-008)

PARTICIPATING ORGANIZATIONS:
National Science Foundation (NSF)
 (http://www.nsf.gov)
Directorate for Computer and Information Science and Engineering
Directorate for Biological Sciences
Directorate for Social, Behavioral, and Economic Sciences 
Directorate for Engineering
Directorate for Mathematical and Physical Sciences

National Institutes of Health (NIH)
 (http://www.nih.gov)
National Institute of Neurological Disorders and Stroke (NINDS)
 (http://www.ninds.nih.gov)
National Institute of Mental Health (NIMH)
 (http://www.nimh.nih.gov)
National Institute on Drug Abuse (NIDA)
 (http://www.nida.nih.gov)
National Institute on Deafness and Other Communication Disorders (NIDCD)
 (http://www.nidcd.nih.gov)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
 (http://www.niaaa.nih.gov)
National Institute on Aging (NIA)
 (http://www.nia.nih.gov)
National Eye Institute (NEI)
 (http://www.nei.nih.gov)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
 (http://www.nibib.nih.gov)
National Institute of Dental and Craniofacial Research (NIDCR)
 (http://www.nidcr.nih.gov)

LETTER OF INTENT RECEIPT DATE (REQUIRED):

December 10, 2003
December 1, 2004
December 1, 2005

PROPOSAL (APPLICATION) RECEIPT DATE:  

January 30, 2004
January 5, 2005
January 5, 2006

This Notice replaces Notice NOT-MH-01-014. 
http://grants.nih.gov/grants/guide/notice-files/NOT-MH-01-014.html

This Notice announces a joint initiative, Collaborative Research in 
Computational Neuroscience (CRCNS), between five National Science 
Foundation (NSF) Directorates and nine participating National 
Institutes of Health (NIH) Institutes. The CRCNS announcement is 
released under NSF 04-514, http://www.nsf.gov/cgi-bin/getpub?nsf04514.  
This announcement supersedes NSF 02-018; Support Collaborative Research 
in Computational Neuroscience (CRCNS). This new announcement differs 
from the prior issuance in that it is effect for three years, and the 
scope of the solicitation is expanded to include the interests of other 
NIH Institutes and NSF Directorates. 

CRCNS will support innovative interdisciplinary research in 
computational neuroscience.  Both agencies recognize the need for 
research that focuses on integrating computational models and methods 
with neuroscience.  This solicitation is designed to encourage new 
collaborations at this interface.  Appropriate scientific areas of 
investigations are those that are currently supported by NSF and NIH, 
or related to the missions of the two agencies.

Computational neuroscience provides a theoretical foundation and set of 
technological approaches that may enhance our understanding of nervous 
system function by providing analytical and modeling tools that 
describe, traverse and integrate different levels of organization, 
spanning vast temporal and spatial scales and levels of abstraction.  
Computational approaches are needed in the study of neuroscience as the 
requirement for comprehensive analysis and interpretation of complex 
data sets becomes increasingly important.  Collaborations among 
computer scientists, engineers, mathematicians, statisticians, 
theoreticians and experimental neurobiologists, are imperative to 
advance our understanding of the nervous system and mechanisms 
underlying brain disorders.

The computational research that will be supported under this program 
must impact on, and relate to biological processes, and optimally 
generate hypotheses that are testable in biological studies.  It is 
expected that, (1) applications will include collaborations between 
computational and/or modeling experts, and neuroscientists; (2) 
collaboration will involve a dynamic and, possibly, a protracted period 
of model development and refinement, and intense interaction among 
scientists and engineers from different disciplines; and (3) the 
development and testing of new models will provide a framework for the 
design of experiments and the generation of new hypotheses that can 
help reveal mechanisms underlying both normal and disease states of the 
nervous system.

AWARD INFORMATION 
 
Estimated program budget, number of awards and average award size and 
duration are subject to the availability of funds. Award sizes are 
expected to range from $100,000 to $500,000 in total cost per year 
(including indirect costs), with durations of 3-5 years.  Most awards 
will be on the smaller end of this range.  The maximum budgets of 
awards funded by the NIH will be $250,000 per year in direct costs.  
The maximum budgets of awards funded by NSF will be $500,000 per year 
in total costs.  

Upon conclusion of the review process, meritorious applications may be 
recommended for funding by either the participating NSF Directorates or 
NIH Institutes, at the option of the agencies, not the applicant. 
 
PROPOSAL PREPARATION AND SUBMISSION INSTRUCTIONS 
 
Letters of Intent (Required):

Letters of intent should be submitted via email to crcns-
[email protected].  The subject line of the e-mail should include the PI's 
and the title of the project.  The body of the email should include:

1. The names and institutions/organizations of PIs, CoPIs, and Senior 
Personnel
2. The title of the project
3. A 250-word abstract of the project

Letters of Intent will be used by the program to guide the selection of 
reviewers. PIs should not expect feedback on their letters of intent, 
beyond acknowledgement of their receipt.

Full Application Instructions:

Applications submitted in response to this program 
announcement/solicitation should be prepared and submitted in 
accordance with the general guidelines contained in the NSF Grant 
Proposal Guide (GPG).  Applications must be submitted to NSF, not the 
NIH.  The complete text of the GPG is available electronically on the 
NSF Web Site at http://www.nsf.gov/cgi-bin/getpub?gpg.  Paper copies of 
the GPG may be obtained from the NSF Publications Clearinghouse, 
telephone (301) 947-2722 or by e-mail from [email protected].  Applicants 
are reminded to identify the program announcement number (04-514) in 
the program announcement block on the NSF Cover Sheet for Proposal to 
the National Science Foundation.  Compliance with this announcement is 
critical to determining the relevant proposal processing guidelines.  
Failure to submit this information may delay processing.

INQUIRIES

Written and telephone inquiries are encouraged.  Please see the NSF 
program announcement for names and contact information for each of the 
participating NSF Directorates and/or NIH Institutes at 
http://www.nsf.gov/cgi-bin/getpub?nsf04514.

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